Evidence map›Paper›PMID 41507783›Full record

ArticleMolecular medicine (Cambridge, Mass.)2026

IL17F

Matthew D Taylor, Omar Geier, Alexandria Z Byskosh, Ekaterina Murzin, Ana Nedeljkovic-Kurepa, Grace M Fisler, Mabel N Abraham, Mariana R Brewer, James A Lederer, Clifford S Deutschman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew D TaylorPediatric Sepsis Research Laboratory, The Feinstein Institutes for Medical Research, 269-01 76th Avenue, Manhasset, NY, USA. mtaylor15@northwell.edu.
Omar GeierPediatric Sepsis Research Laboratory, The Feinstein Institutes for Medical Research, 269-01 76th Avenue, Manhasset, NY, USA.
Alexandria Z ByskoshDepartment of Surgery, Brigham and Women's Hospital, 269-01 76th Avenue, Boston, MA, USA.
Ekaterina MurzinDepartment of Surgery, Brigham and Women's Hospital, 269-01 76th Avenue, Boston, MA, USA.
Ana Nedeljkovic-KurepaPediatric Sepsis Research Laboratory, The Feinstein Institutes for Medical Research, 269-01 76th Avenue, Manhasset, NY, USA.
Grace M FislerPediatric Sepsis Research Laboratory, The Feinstein Institutes for Medical Research, 269-01 76th Avenue, Manhasset, NY, USA.
Mabel N AbrahamPediatric Sepsis Research Laboratory, The Feinstein Institutes for Medical Research, 269-01 76th Avenue, Manhasset, NY, USA.
Mariana R BrewerPediatric Sepsis Research Laboratory, The Feinstein Institutes for Medical Research, 269-01 76th Avenue, Manhasset, NY, USA.
James A LedererDepartment of Surgery, Brigham and Women's Hospital, 269-01 76th Avenue, Boston, MA, USA.
Clifford S DeutschmanPediatric Sepsis Research Laboratory, The Feinstein Institutes for Medical Research, 269-01 76th Avenue, Manhasset, NY, USA.

Funding

Orexinergic Modulation of Experimental SepsisR01GM121102 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DEUTSCHMAN, CLIFFORD SCOTT, PAVLOV, VALENTIN ATANASSOV · 2017 to 2020
$1.6M
T Cell Receptor Mediated T Cell Activation in Neonatal and Pediatric SepsisR35GM157197 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Matthew David Taylor · 2025 to 2026
$838k
Effects of Memory T Cells on the Response to Cecal Ligation and PunctureK08GM132794 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI TAYLOR, MATTHEW DAVID · 2019 to 2022
$782k
NIGMS NIH HHS K08 GM132794NIGMS NIH HHS R01 GM 121102NIGMS NIH HHS R01 GM121102NIGMS NIH HHS R35 GM157197Thrasher Research Fund 14734
6 · The paper itself

Abstract

T cell memory significantly alters the immune response and organ dysfunction induced by the murine cecal ligation and puncture (CLP) model of sepsis. Enhanced T cell memory activation promotes hepatic neutrophilic responses and induces hepatic dysfunction, which is a common complication of human sepsis associated with poor outcomes. We used a novel Immune Educated CLP sepsis mouse model to examine the role of memory T cell cytokine responses in driving innate immunity and organ dysfunction. Through this approach, we found that induced T cell memory prior to CLP led to higher serum levels of IL12, TNF, IL17, and IL1β – all dependent on memory CD8 T cell derived IFNγ following CLP. IFNγ induced activated hepatic IL12+ monocyte-derived dendritic cells. Increased neutrophilic responses occurred in Educated CLP which was found to depend on TNF, and were suppressed by IFNγ. Hepatic dysfunction in response to CLP was worsened by CD4 and CD8 T cell immune memory and prevented by IFNγ and IL17F blockade. These findings were recapitulated in naturalized outbred pet shop mice with natural immune memory to provide translational relevance to our Immune Educated CLP sepsis model. IL17F or IFNγ blockade may represent potential targets for treatment in sepsis with hepatic dysfunction.

Indexed as

CD8-Positive T-LymphocytesImmunologic MemoryInterferon-gammaInterleukin-17LiverLiver DiseasesMemory T CellsSepsisAnimalsCecumDisease Models, AnimalLigationMaleMiceMice, Inbred C57BLPuncturesInterferon-gammaInterleukin-17Cecal ligation and punctureCLPIFNγIL17FInflammationLiver dysfunctionSepsisT cell memory

Identifiers

PMID41507783
PMCPMC12870529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.