Evidence map›Paper›PMID 41507695›Full record

Trial reportActa physiologica (Oxford, England)2026

Human Skeletal Muscle Mitochondria Responses to Weight Loss Induced by Bariatric Surgery or Lifestyle Intervention.

Birgitta W van der Kolk, Sini Heinonen, James W White, Anita Wagner, Jari E Karppinen, Sina Saari, Maheswary Muniandy, Simo Metsikkö, Eugène T Dillon, Per-Henrik Groop and 7 more

2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01312090 nacompletednot on this map

Chronic Intermittent Cold Exposure on Weight Loss

TypeinterventionalSponsorHelsinki University Central HospitalRan2010 to 2011Enrolled20ConditionsObesityArmsWhole body cryotherapy, counseling and behavioral therapy for weight loss
NCT02882685 naactive not recruitingnot on this map

Comparison of Two Operative Techniques - Mini Gastric Bypass and Roux-en-Y Gastric Bypass in the Treatment of Severe Obesity

TypeinterventionalSponsorHelsinki University Central HospitalRan2016 to 2026Enrolled120ConditionsMorbid ObesityArmsRoux-en-y gastric bypass, Single anastomosis gastric bypass
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Birgitta W van der KolkResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-8608-541X
Sini HeinonenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
James W WhiteDiabetes Complications Research Centre, School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Anita WagnerResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Jari E KarppinenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-9886-9067
Sina SaariResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Maheswary MuniandyResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Simo MetsikköResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Eugène T DillonMass Spectrometry Resource, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland.
Per-Henrik GroopResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Tuure SaarinenDepartment of Gastrointestinal Surgery, Abdominal Center, HUS and University of Helsinki, Helsinki, Finland.
Carel W Le RouxDiabetes Complications Research Centre, School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Kirsi A VirtanenTurku PET Centre, Turku University Hospital, Turku, Finland.
Neil G DochertyDiabetes Complications Research Centre, School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Eija PirinenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Anne JuutiDiabetes Complications Research Centre, School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Kirsi H PietiläinenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-8522-1288

Funding

Finnish Diabetes Research FoundationFinnish Foundation for Cardiovascular ResearchFinnish Medical FoundationGovernment Research FundsHelsinki University Hospital Research FundsNovo Nordisk Foundation NNF10OC1013354Novo Nordisk Foundation NNF17OC0027232Novo Nordisk Foundation NNF20OC0060547Novo Nordisk Foundation NNF23SA0083953Novo Nordisk Foundation NNF24OC0091683Novo Nordisk Foundation NNF24SA0090438Novo Nordisk Foundation NNF25OC0100827Novo Nordisk Foundation NNF25SA0103783Orion Foundation SrPaavo Nurmi FoundationPaulo FoundationResearch Council of Finland 259926Research Council of Finland 265204Research Council of Finland 266286Research Council of Finland 272376Research Council of Finland 292839Research Council of Finland 314383Research Council of Finland 314455Research Council of Finland 314456Research Council of Finland 314457Research Council of Finland 335443Research Council of Finland 335445Research Council of Finland 335446Research Council of Finland 336449Research Council of Finland 338417Research Council of Finland 361956Research Council of Finland 369181Sigrid Juselius FoundationUniversity of Helsinki
6 · The paper itself

Abstract

aimWe investigated how weight loss induced by bariatric surgery or lifestyle intervention affects skeletal muscle mitochondrial metabolism.

methodsWe studied two weight-loss cohorts: RYSA (BMI ≥ 35 kg/m

resultsBoth cohorts achieved clinically meaningful weight loss, greater following surgery (24.4% vs 9.0% at 12 months). Per 1% weight loss, bariatric surgery was associated with significant downregulation of glycolysis pathways at 12 months. OXPHOS complex subunit proteins were associated with upregulation in individuals without diabetes but downregulation in those with diabetes. Lifestyle intervention was associated with downregulated OXPHOS complex subunits at 5 months. Mitochondrial morphology remained unchanged, while mtDNA amount correlated negatively with weight loss percentage in both cohorts. In the surgery cohort, complex I and complex I + II-mediated respiration increased 3.2- and 2.9-fold at 12 months, reflecting improved oxidative capacity.

conclusionBariatric surgery was associated with increased skeletal muscle mitochondrial respiration despite unchanged morphology and reduced mtDNA amount, whereas lifestyle-induced weight loss showed a transient downregulation of OXPHOS-related proteins with other mitochondrial markers remaining stable. Surgery-induced weight loss may reflect improved mitochondrial efficiency in skeletal muscle, potentially influenced by diabetes status. Long-term functional mitochondrial adaptations after weight loss require future studies.

trial registrationRYSA: ClinicalTrials.gov ID NCT02882685; CRYO: ClinicalTrials.gov ID NCT01312090.

Indexed as

Bariatric SurgeryLife StyleMitochondria, MuscleMuscle, SkeletalWeight LossAdultFemaleHumansMaleMiddle AgedObesitybariatric surgerylifestyle interventionmitochondriaskeletal muscletype 2 diabetesweight loss

Identifiers

PMID41507695
PMCPMC12783452

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.