Evidence map›Paper›PMID 41507693›Full record

ArticleThe Journal of infectious diseases2026

Characterization of Mouse-Adapted Marburg and Ravn Viruses in Inbred BALB/c and Outbred CD-1 Mice.

Katherine A Davies, Stephen R Welch, JoAnn D Coleman-McCray, Teresa E Sorvillo, Virginia Aida-Ficken, Shilpi Jain, César G Albariño, Biao He, Christina F Spiropoulou, Jessica R Spengler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katherine A DaviesViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-1643-7093
Stephen R WelchViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-6905-8521
JoAnn D Coleman-McCrayViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0003-0396-2224
Teresa E SorvilloViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0003-2943-4040
Virginia Aida-FickenForeign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, National Bio and Agro-Defense Facility, United States Department of Agriculture, Manhattan, Kansas, USA.ORCID 0000-0001-9450-0142
Shilpi JainViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-5638-0298
César G AlbariñoViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-8013-1785
Biao HeDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.ORCID 0000-0001-8336-7171
Christina F SpiropoulouViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0001-8406-3161
Jessica R SpenglerViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-5383-0513

Funding

CDC Emerging Infectious Disease Research Core FundsFred C. Davison Distinguished University ChairOak Ridge Associated UniversitiesOak Ridge Institute for Science and EducationU.S. Department of Agriculture-Agricultural Research ServiceU.S. Department of Energy
6 · The paper itself

Abstract

Marburgviruses cause severe hemorrhagic disease in humans, yet characterization of rodent models for pathogenesis and medical countermeasure development remains limited. Here, we investigated clinical course, blood chemistry, viral dissemination, and mucosal viral detection in inbred BALB/c and outbred CD-1 mice infected with mouse-adapted (MA)-Marburg virus (MARV)/Angola or MA-Ravn virus (RAVV) to further mouse model development. Regardless of virus or mouse strain, infection resulted in widespread viral dissemination in animals sampled up to 5 days post-infection. However, in animals followed to study end, MA-MARV/Angola caused severe disease and lethality in both mouse strains, whereas MA-RAVV caused mild or asymptomatic infection.

Indexed as

MarburgvirusMarburg Virus DiseaseAnimalsDisease Models, AnimalFemaleMiceMice, Inbred BALB CBALB/c miceCD-1 micefilovirusMarburg virusRavn virus

Identifiers

PMID41507693
PMCPMC13175610

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.