Evidence map›Paper›PMID 41507690›Full record

ArticleJournal of cardiovascular translational research2026

Extension of Atherosclerosis ApoE-/- Mouse-a Model of Chronic Myocardial Ischemia and Evaluation Method.

Zhaobo Wang, Peixun Zheng, Qian Lin, Hongxin Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhaobo WangDongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China.
Peixun ZhengDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
Qian LinDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
Hongxin CaoInstitute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China. caohongxin2024@163.com.ORCID 0009-0007-0939-7656

Funding

Project of China Academy of Chinese Medical Science 2024003
6 · The paper itself

Abstract

Chronic myocardial ischemia (CMI) is a key pathological condition in coronary artery disease (CAD), yet small animal models for CMI are limited. This study developed and characterized a CMI mouse model using ApoE-/- mice fed a high-fat diet for 3 months. Cardiac function was assessed through electrocardiography (ECG), myocardial action potential, and perfusion echocardiography. The model group exhibited elevated cholesterol, aortic lipid plaques, and T-wave flattening, correlated with atherosclerosis severity. Impaired myocardial perfusion, reduced ATP content, and accelerated inner cardiomyocyte repolarization were also observed. PET/CT scans revealed filling defects, while myocardial contractile function showed reactive suppression under CMI conditions. This model replicates CMI's pathological features, providing a valuable tool for studying CAD progression and treatment.

Indexed as

Aortic DiseasesAtherosclerosisCoronary Artery DiseaseMyocardial IschemiaAction PotentialsAdenosine TriphosphateAnimalsApolipoproteins EChronic DiseaseCoronary CirculationDiet, High-FatDisease Models, AnimalElectrocardiographyGenetic Predisposition to DiseaseMaleMice, Inbred C57BLAdenosine TriphosphateApoe protein, mouseApolipoproteins EChronic myocardial ischaemiaCoronary artery diseaseElectrocardiographyExperimental model

Identifiers

PMID41507690
PMCPMC12858496

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.