Association between serum lipids and colorectal polyps: a retrospective cross-sectional study.

Maolang He, Shuxin Tian, Shangqi Wang, Rui Huo

Abstract read

In one paragraph

Article in International journal of colorectal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

HDL-C presents a suggestive negative moderating trend for the association between total cholesterol and colorectal polyps: model construction and bootstrap internal assessment of a predictive nomogram.Frontiers in endocrinology · 2026
Article

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5 · Who and what money

Authors and funding

4 authors.

Maolang HeDepartment of Gastroenterology, The First Affiliated Hospital of Shihezi University, Shihezi, 832008, China.

Shuxin TianDepartment of Gastroenterology, The First Affiliated Hospital of Shihezi University, Shihezi, 832008, China.

Shangqi WangSchool of Medicine, Shihezi University, Shihezi, 832002, China.

Rui HuoDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Shihezi University, Shihezi, 832008, China. huodoctor@shzu.edu.cn.ORCID http://orcid.org/0009-0001-5292-7970

Funding

National Natural Science Foundation of China 82460539Science and Technology Bureau of Xinjiang Production and Construction Corps 2022ZD023Science and Technology Bureau of Xinjiang Production and Construction Corps 2022ZD038Science and Technology Bureau of Xinjiang Production and Construction Corps BTYJXM-2024-S26

6 · The paper itself

Abstract

backgroundThe relationship between serum lipids and colorectal polyps (CP) remains unclear due to inconsistent findings across prior studies. This study aimed to comprehensively explore the relationship between serum lipid levels and CP risk by using real-world clinical data.

methodsBy utilizing retrospective data from a tertiary hospital from 2015 to 2024, multivariate logistic regression, restricted cubic spline (RCS), and subgroup analyses were performed to assess the association between serum lipids and CP. Additionally, the mediating role of inflammation-related indices in the relationship between serum lipids and CP was examined.

resultsTriglyceride (TG) and total cholesterol (TC) were positively associated with CP risk (P < 0.05). RCS analysis revealed a nonlinear dose-response relationship between TG and CP risk (P for overall < 0.001, nonlinear P < 0.05), with a threshold value of 0.93 mmol/L. Significant interaction effects were observed between TG and TC and gender in relation to CP development. Inflammation-related indices mediated the association between high-density lipoprotein cholesterol and TC with CP risk (P < 0.05).

conclusionThis study highlights the potential clinical utility of TG and TC as modifiable biomarkers for CP risk. Future prospective studies are warranted to validate these findings and to explore targeted lipid-modifying interventions for high-risk populations.

Indexed as

Colonic PolypsLipidsAgedCholesterolCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTriglyceridesCholesterolLipidsTriglyceridesColorectal polypsCross-sectional studyInflammationRisk factorSerum lipids

Identifiers

PMID41507680

DOI10.1007/s00384-025-05056-9

PMCPMC12783160

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.