Evidence map›Paper›PMID 41507601›Full record

ReviewCurrent allergy and asthma reports2026

Chronic Rhinosinusitis Optimisation of Nasal Outcomes and Scores (CHRONOS): An Italian Delphi Consensus on Long-Term Management with Biologics.

Eugenio De Corso, Frank Rikki Mauritz Canevari, Marco Caminati, Carlotta Pipolo, Enrico Heffler, Matteo Lazzeroni, Veronica Seccia, Massimiliano Garzaro, Giancarlo Ottaviano, Elena Cantone and 23 more

Abstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Switching to dupilumab from other biologic therapies in chronic rhinosinusitis with nasal polyps (CRSWNP): a comparison with biologic-naïve patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Eugenio De CorsoUnit of Otorhinolaryngology and Head-Neck Surgery, A Gemelli University Hospital Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0001-5761-7018
Frank Rikki Mauritz CanevariUnit of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Marco CaminatiAllergy Unit and Asthma Center, Integrated University Hospital of Verona, Verona, Italy. marco.caminati@univr.it.ORCID http://orcid.org/0000-0001-7383-1487
Carlotta PipoloOtolaryngology Unit, Department of Health Sciences, Santi Paolo E Carlo Hospital, Università Degli Studi Di Milano, Milan, Italy.
Enrico HefflerDepartment of Biomedical Science, Humanitas University, Pieve Emanuele (Milan), Italy.
Matteo LazzeroniDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Veronica SecciaAudiology and Phoniatric Operative Unit, Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, Azienda Ospedaliera Universitaria Pisana, University of Pisa, OtolaryngologyPisa, Italy.
Massimiliano GarzaroENT Division, Eastern Piedmont University Hospital of Novara, Novara, Italy.
Giancarlo OttavianoOtolaryngology Section, Department of Neurosciences, University of Padova, Padua, Italy.
Elena CantoneOtolaryngology Unit Department of Pharmacy and Health and Nutrition Sciences, University of Calabria, Rende, Italy.
Fabio PagellaDepartment of Surgical Pediatric Science, University of Pavia, Pavia, Italy.
Giulia GramelliniOtolaryngology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Ignazio La MantiaDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", ENT Section, University of Catania, Catania, Italy.
Stefania GalloUnit of Otorhinolaryngology, Head and Neck Department, ASST Sette Laghi, Varese, Italy.
Antonio MoffaSchool of Medicine, Università Campus Bio-Medico, Rome, Italy.
Ernesto PasquiniENT Unit, Bellaria Hospital, Azienda USL Bologna, Bologna, Italy.
Antonella LoperfidoOtolaryngology Unit, San Camillo Forlanini Hospital, Rome, Italy.
Sara TorrettaDepartment of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Lorenzo CecchiAllergology and Clinical Immunology, S Giovanni Di Dio Hospital, Florence, Italy.
Gian Luca FaddaDepartment of Otorhinolaryngology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy.
Giandomenico MaggioreDepartment of Otorhinolaryngology, Careggi University Hospital, Florence, Italy.
Stefano PelucchiOtorhinolaryngology and Audiology Unit, Department of Neurosciences and Rehabilitation, University of Study of Ferrara, Ferrara, Italy.
Lucia IannuzziDepartment of Biomedical Sciences, Neurosciences and Sense Organs, ENT Clinic, University of Bari, Bari, Italy.
Daniela LucidiBologna University- ENT Department Ravenna Hospital, Bologna, Italy.
Alberto MacchiUnit of Otorhinolaryngology, Head and Neck Department, ASST Sette Laghi, Varese, Italy.
Roberto PadoanDepartment of Medicine DIMED, Rheumatology Unit, University of Padua, Padua, Italy.
Vincenzo PatellaDepartment of Internal Medicine ASL Salerno, 'Santa Maria Della Speranza' Hospital, Battipaglia, Italy.
Giulia DanéOtorhinolaryngology Unit, Head and Neck Department, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Jan SchroederAllergology and Clinical Immunology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Claudio MontuoriUniversità Cattolica Del Sacro Cuore, Istituto Di Otorinolaringoiatria, Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
Marco CorbòUnit of Otorhinolaryngology and Head-Neck Surgery, A Gemelli University Hospital Foundation IRCCS, Rome, Italy.
Giorgio Walter CanonicaDepartment of Biomedical Science, Humanitas University, Pieve Emanuele (Milan), Italy.
Gianenrico SennaDepartment of Medicine, University of Verona, Verona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review synthesizes current evidence and expert consensus on the long-term management of severe chronic rhinosinusitis with nasal polyps (CRSwNP) treated with biologics, as established by the Italian CHRONOS project. RECENT

findingsAccumulating real-world and clinical trial data confirm the sustained efficacy and safety of biologics targeting type 2 inflammation, enabling durable control and remission in a significant proportion of patients. Personalized dosing regimens, including dose-spacing strategies, appear feasible. The CHRONOS project provides practical guidance for optimizing long-term biologic therapy in severe CRSwNP. Response assessment should combine subjective and objective measures, especially for olfactory testing. Biologics may be considered before surgery only in selected complex cases. Dose-spacing strategies may be appropriate in stable patients but require multidisciplinary oversight in those with comorbid asthma. Adverse events are uncommon. The concept of disease modification is endorsed, recognizing biologics' potential to alter the natural history of CRSwNP.

Indexed as

Biological ProductsNasal PolypsRhinitisRhinosinusitisSinusitisChronic DiseaseHumansItalyTreatment OutcomeBiological ProductsBiological therapyChronic rhinosinusitis with nasal polypsDisease modificationDupilumabLong-term managementMepolizumabOmalizumabRemissionType 2 inflammation

Identifiers

PMID41507601

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.