Evidence map›Paper›PMID 41507598›Full record

ArticleJournal of neurology2026

Survival and related factors in patients with Parkinson's disease: a multicenter prospective cohort study in China.

Tingwei Song, Linghui Xiang, Yuan Liu, Hongxu Pan, Yiting Wu, Xiaoyun Li, Fei Luo, Chunyu Wang, Lifang Lei, Lingyan Yao and 10 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Tingwei Song *Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Linghui Xiang *Department of Epidemiology and Health Statistic, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Yuan LiuHunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, China.
Hongxu PanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yiting WuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiaoyun LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Fei LuoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chunyu WangDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lifang LeiDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lingyan YaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yuwen ZhaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhenhua LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qiying SunDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jifeng GuoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Irene X Y WuDepartment of Epidemiology and Health Statistic, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Li YinHunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, China. hnyl007@qq.com.
Xiaoxia ZhouDepartment of Nuclear Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. zhouxiaoxia6988@163.com.
Qian XuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China. xyxuqian2015@csu.edu.cn.
for Parkinson’s Disease, Movement Disorders Multicenter Database, Collaborative Network in China (PD-MDCNC)

Funding

Hunan Innovative Province Construction Project 2021SK1010Hunan Innovative Province Construction Project 2023JJ10098Hunan Innovative Province Construction Project 2023SK2037National Natural Science Foundation of China 82071437National Natural Science Foundation of China 82171256National Natural Science Foundation of China 82327805
6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease and the fastest-growing disability-causing neurological disorder worldwide. Based on the CPDR cohort from 19 clinical centers, we summarized the mortality information and characteristics of patients with PD, and analyzed the related factors affecting their survival. After a 6-year follow-up period, 562 of the 3,148 patients died, with a mortality rate of 3.03 deaths per 100 person-years, and a median survival time from disease onset of 23.33 years. The most common cause of death was cardiovascular disease, followed by cerebrovascular disease and respiratory disease. Older age at onset, carriers of GBA1 gene variants, type 2 diabetes, higher LEDD, late H&Y stage (especially H&Y stage 4 and H&Y stage 5), higher UPDRS part Ⅲ scores, a history of falls, depression, and cognitive dysfunction were associated with increased mortality. In contrast, undergoing deep brain stimulation (DBS) surgery and higher educational attainment was associated with a lower risk of death. Our findings contributed to further expanding the survival data of PD and advocated for early identification of high-risk patients for timely intervention to improve prognosis.

Indexed as

Parkinson DiseaseAdultAgedAged, 80 and overChinaCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesMortalityParkinson’s diseasePrognosisRelated factorsSurvival

Identifiers

PMID41507598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.