ReviewPflugers Archiv : European journal of physiology2026
Acid-Base homeostasis in the brain: regional heterogeneity and different Acid-Base transporters.
Review in Pflugers Archiv : European journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Direct energy consumption by inhibitory GABAFrontiers in neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain employs a sophisticated and multi-layered system to maintain its delicate acid-base balance, ensuring optimal conditions for neuronal and glial function. This intricate regulation involves a combination of chemical buffering, active transport mechanisms, and systemic controls. The balance of pH in mammalian cells is vital for the control of metabolism, as hydrogen and hydroxyl ions are essential. It is important for the nervous system to keep its pH in a neutral range (7.2-7.6) for proper function. Even small pH changes can impact neuron activity, synaptic transmission, and communication between cells. Many membrane proteins sensitive to pH changes play vital roles in neurotransmission. Recent research has identified pH-sensitive proteins that respond to acidic (pH 5) and alkaline (pH 9) conditions, influencing various cellular activities. This review discusses these pH-sensitive proteins in neurons.
Indexed as
Identifiers
41507581What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.