Evidence map›Paper›PMID 41507580›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Long-term optic nerve head microvascular impairment after acute primary angle closure: an OCTA study.

Yue Ying, Xintong Fan, Yanan Sun, Qilian Sheng, Ye Lin Kwan, Mengrui Hao, Xiangmei Kong

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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yue YingEye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Rd., Shanghai, 200031, China.
Xintong FanEye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Rd., Shanghai, 200031, China.
Yanan SunEye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Rd., Shanghai, 200031, China.
Qilian ShengEye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Rd., Shanghai, 200031, China.
Ye Lin KwanEye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Rd., Shanghai, 200031, China.
Mengrui HaoEye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Rd., Shanghai, 200031, China.
Xiangmei KongEye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Rd., Shanghai, 200031, China. kongxm95@163.com.ORCID http://orcid.org/0000-0002-8142-6040

Funding

National Natural Science Foundation of China 82070957Shanghai Health Science Popularization Leading Talents' Ability Promotion Project JKKPYL-2024-B02
6 · The paper itself

Abstract

purposeWhile previous studies documented transient reductions in fundus vessel density (VD) following acute primary angle closure (APAC), we investigated whether optic nerve head (ONH) and macular VD was lower long-term following APAC. The study aimed to describe long-term microvascular patterns after APAC and identify anatomical regions showing lower VD.

methodsResolved APAC, primary angle closure suspects (PACS), and age-sex-matched healthy controls were enrolled. Quantitative microvascular assessment was performed using spectral domain optical coherence tomography angiography (OCTA) system (RTvue XR Avanti; Optovue, Fremont, CA, USA), with 4.5*4.5 mm ONH and 3.0*3.0 mm macular scan protocols. Peripapillary VD was analyzed as the primary endpoint, while sectoral ONH VD and macular VD were evaluated as secondary measures.

resultsThe median and range of interval between APAC onset and examination was 15, (1, 60) months. APAC eyes demonstrated marked reduction in peripapillary VD compared with PACS and controls. Macular VD was less affected. ONH VD positively correlated with structural parameters in APAC eyes.

conclusionDespite clinical resolution of APAC, peripapillary VD was lower in eyes with previous APAC compared with PACS and controls.

Indexed as

Fluorescein AngiographyGlaucoma, Angle-ClosureIntraocular PressureMicrovesselsOptic DiskRetinal VesselsTomography, Optical CoherenceAcute DiseaseAgedFemaleFollow-Up StudiesFundus OculiHumansMaleMiddle AgedTime FactorsAcute primary angle closureFundus microvasculatureOptical coherence tomography angiographyPrimary angle closure suspect

Identifiers

PMID41507580

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.