ArticleNature medicine2026
Immune profiling in a living human recipient of a gene-edited pig kidney.
Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Addressing evidence gaps in haemodialysis care: a critical review of clinical trials, technological innovations, and implementation priorities.BMC nephrology · 2026Article
- Longitudinal multiomics profiling of extracorporeal cross-circulation with pig liver xenografts in human decedents.Nature medicine · 2026Article
- [A brief discussion on microsurgery techniques and free perforator flaps for wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- Present Advances and Emerging Challenges in Kidney Xenotransplantation.Journal of clinical medicine · 2026Review
- Hypoimmune platforms: from rejection to immune evasion and regulatory implications.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- Porcine xenotransplantation in the clinical era: converging advances and unresolved barriers on the path to clinical translation - a narrative review.Frontiers in immunology · 2026Review
- Artificial Intelligence in Xenotransplantation: A Prioritized Roadmap for Early Clinical Translation, Opportunities and Challenges.XenotransplantationReview
- Xenotransplantation Literature Update: January-June 2026.XenotransplantationReview
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
Xenotransplantation of gene-edited pig kidneys offers a promising solution to the shortage of kidneys for organ transplantation. We recently performed a gene-edited pig kidney transplantation into a living human recipient with end-stage kidney disease. Here, using transcriptomics, proteomics, metabolomics and multiplexed imaging, we conducted high-dimensional immune profiling in this individual. Despite profound depletion of circulating T cells, early T cell-mediated rejection occurred within 1 week after transplantation, likely driven by subtherapeutic immunosuppression and the presence of residual CD8
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.