Evidence map›Paper›PMID 41507574›Full record

Trial reportNature medicine2026

Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial.

Rouchelle S Sriranjan-Rothwell, Tian X Zhao, Stephen P Hoole, Simon J Bond, Jason M Tarkin, Jacob Brubert, Annette Hubsch, Joanna Helmy, Elaine Bumanlag-Amis, Navazh Jalaludeen and 13 more

Abstract readRandomized Controlled TrialClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Translating Nobel Prize-winning TNature cardiovascular research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Rouchelle S Sriranjan-RothwellDivision of Cardiology, Royal Papworth Hospital, Cambridge, UK.
Tian X Zhao *Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0202-5255
Stephen P Hoole *Division of Cardiology, Royal Papworth Hospital, Cambridge, UK.ORCID http://orcid.org/0000-0002-3530-3808
Simon J BondCambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Jason M TarkinDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9132-120X
Jacob BrubertDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1207-7446
Annette HubschCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Joanna HelmyCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Elaine Bumanlag-AmisCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Navazh JalaludeenCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Heike TemplinCambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Wei JiangDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6119-3331
Alain TedguiINSERM U970, Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-7229-4875
Xiaohui ZhaoDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9922-2815
Meritxell NusDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6378-8910
Victoria WarnesCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Unni KrishnanDivision of Cardiology, Royal Papworth Hospital, Cambridge, UK.
James W O'BrienDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7231-8988
Christopher WallDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
James H F RuddCambridge University Hospitals NHS Foundation Trust, Cambridge, UK. jhfr2@cam.ac.uk.ORCID http://orcid.org/0000-0003-2243-3117
Joseph CheriyanCambridge University Hospitals NHS Foundation Trust, Cambridge, UK. jc403@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0001-6921-1592
Ziad MallatDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK. zm255@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0003-0443-7878
IVORY investigators

Funding

British Heart Foundation (BHF) IA/F/23/275046British Heart Foundation (BHF) PG/22/10898British Heart Foundation (BHF) RE/24/130011DH | National Institute for Health Research (NIHR) 203312RCUK | Medical Research Council (MRC) MR/N028015/1Wellcome Trust (Wellcome) 211100/Z/18/Z
6 · The paper itself

Abstract

Regulatory T (T

Indexed as

Acute Coronary SyndromeAnti-Inflammatory AgentsInterleukin-2AgedC-Reactive ProteinDouble-Blind MethodFemaleFluorodeoxyglucose F18HumansInflammationMaleMiddle AgedPositron Emission Tomography Computed TomographyT-Lymphocytes, RegulatoryAnti-Inflammatory AgentsC-Reactive ProteinFluorodeoxyglucose F18Interleukin-2

Identifiers

PMID41507574
PMCPMC12920103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.