Evidence map›Paper›PMID 41507495›Full record

Observational studyAesthetic plastic surgery2026

Redefining Labiaplasty: New Anatomical Classification and Innovative Treatment Algorithm for Vulvar Aging.

Mattia Siliprandi, Elisa Maria Ragaini, Flavio Bucci, Valeriano Vinci, Andrea Vittorio Emanuele Lisa, Francesco Klinger, Luca Siliprandi

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mattia SiliprandiIRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, MI, Italy.
Elisa Maria RagainiIRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, MI, Italy. elisa.ragaini@gmail.com.ORCID http://orcid.org/0000-0003-1043-8690
Flavio BucciIRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, MI, Italy.
Valeriano VinciIRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, MI, Italy.
Andrea Vittorio Emanuele LisaDepartment of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, 20090, Pieve Emanuele, MI, Italy.
Francesco KlingerDepartment of Health Sciences, Ospedale San Paolo, University of Milan, Via Antonio di Rudinì, Milan, Italy.
Luca SiliprandiCittàgiardino clinic, Via F. Piccoli, 6, 20123, Padova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLabiaplasty has emerged as a widely accepted procedure for addressing both aesthetic and functional concerns of the female external genitalia. However, the heterogeneity of vulvar aging patterns presents a challenge for standardized surgical planning. To address this, we developed a novel six-type clinical classification of vulvar aging aimed at guiding individualized surgical strategies.

methodsWe conducted a multicenter observational study over an eight-year period (2016-2024) across two private aesthetic surgery centers in Italy. A total of 142 patients presenting with vulvar complaints underwent clinical evaluation, photographic documentation, and surgical intervention. Of these, 14 were excluded due to incomplete follow-up or documentation, leaving 128 patients for final analysis. Patients were classified into one of six clinical types based on labial morphology, including hypertrophy, hypotrophy, and tissue laxity. Surgical techniques were selected according to classification type and included established and customized procedures.

resultsType 1 (isolated labia minora hypertrophy) was the most common presentation (32.8%), followed by Type 2 (labia majora hypotrophy, 21.9%) and Type 3 (combined hypotrophy and hypertrophy, 17.2%). Tailored surgical approaches-ranging from resection and lifting to volumization-were applied. The overall satisfaction rate was 91.4%, with complication rates remaining low (7.8%), including minor wound dehiscence, transient edema, and fat graft resorption. Functional improvements and enhanced body confidence were reported in over 80% of sexually active patients.

conclusionsThis study introduces a new clinical classification of vulvar aging that enables precise, anatomy-based surgical planning in labiaplasty. The system proved practical, reproducible, and closely aligned with patient-reported outcomes. Its implementation may standardize future research and improve the personalization of vulvar aesthetic surgery. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

AgingPlastic Surgery ProceduresVulvaAdultAgedAlgorithmsEstheticsFemaleHumansHypertrophyItalyMiddle AgedPatient SatisfactionRetrospective StudiesTreatment OutcomeAnatomical classificationLabia majora hypotrophy and laxityLabiaplastyPersonalized surgical algorithmVulvar agingVulvar rejuvenation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.