ArticleBulletin of experimental biology and medicine2025
The Effect of β-D-Glucans of Pleurotus ostreatus (Oyster Mushroom) on the Development of Myelosuppression and Colitis Induced by 5-Fluorouracil in Mice.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We studied the effect of the water-soluble fraction of the extract containing β-glucans from Pleurotus ostreatus (oyster mushroom) on myelosuppression and colitis induced by 5-fluorouracil (5-FU) in male BALB/c mice. A decrease in the toxic effect of 5-FU was observed after single oral administration of the extract at a dose of 500 mg/kg. Treatment with 5-FU led to body weight loss by 7% relative to the initial value on day 21, while after addition of the extract with β-glucans, we observed an increase in body weight by 1% by that time in parallel with normalization of blood erythrocyte count. In mice treated with the extract containing β-glucans, the severity of the toxic effect of 5-FU on the colonic mucosa was significantly reduced on day 21: 99.7 ± 1.2 vs 91.8 ± 1.7 viable crypts in animals receiving 5-FU alone (p < 0.01). The results of the study prove the possibility of using β-D-glucans of P. ostreatus extract for the prevention and treatment of gastrointestinal side effects of antitumor drugs.
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