Evidence map›Paper›PMID 41507486›Full record

ArticleBulletin of experimental biology and medicine2025

Immunomodulatory Activity of Lantibiotics Isolated from Growth Media of Coagulase-Negative Staphylococci In Vitro.

S V Gein, T V Polyudova, M V Ibatullin

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

S V GeinInstitute of Ecology and Genetics of Microorganisms, Ural Branch of Russian Academy of Sciences - Branch of Perm Federal Research Center, Ural Branch of Russian Academy of Sciences, Perm, Russia. gein@iegm.ru.
T V PolyudovaInstitute of Ecology and Genetics of Microorganisms, Ural Branch of Russian Academy of Sciences - Branch of Perm Federal Research Center, Ural Branch of Russian Academy of Sciences, Perm, Russia.
M V IbatullinInstitute of Ecology and Genetics of Microorganisms, Ural Branch of Russian Academy of Sciences - Branch of Perm Federal Research Center, Ural Branch of Russian Academy of Sciences, Perm, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lantibiotics warnerin and hominin isolated from growth media of Staphylococcus warneri DSMZ 16081 and S. hominis GISK 284, respectively, have pronounced immunomodulatory effects. Both peptides significantly modulated the microbicidal potential of leukocytes; the effect depended on the concentration and presence of the inducer. Warnerin inhibited ROS in high concentrations and stimulated ROS production in low concentrations in both spontaneous and stimulated samples. Hominin, on the contrary, enhanced spontaneous ROS production, but inhibited stimulated ROS production. Both peptides decreased the phagocytic activity of monocytes and neutrophils and activated the spontaneous production of both pro- (IL-1β, IL-6) and anti-inflammatory (IL-10) cytokines. Comparison of the two peptides revealed that hominin showed higher immunomodulatory activity.

Indexed as

BacteriocinsImmunologic FactorsStaphylococcusCoagulaseCulture MediaHumansInterleukin-10Interleukin-1betaInterleukin-6MonocytesNeutrophilsPhagocytosisReactive Oxygen SpeciesBacteriocinsCoagulaseCulture MediaImmunologic FactorsInterleukin-10Interleukin-1betaInterleukin-6Reactive Oxygen Speciescytokineslantibioticsmonocytesneutrophilsphagocytosis

Identifiers

PMID41507486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.