Evidence map›Paper›PMID 41507477›Full record

ArticleBulletin of experimental biology and medicine2025

Impaired Morphological and Functional Maturation of the Spleen during Puberty in Rats Exposed to Low Doses of Endocrine Disruptor DDT.

B B Gagulaeva, N V Yaglova, S S Obernikhin, E P Timokhina, S V Nazimova, V V Yaglov

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

B B GagulaevaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
N V YaglovaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia. yaglova@mail.ru.
S S ObernikhinAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
E P TimokhinaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
S V NazimovaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
V V YaglovAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The morphological and functional parameters of the spleen development during pubertal period were studied in rats exposed to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) in the prenatal and postnatal periods. Despite the spleen weight and the amount of lymphoid tissue in it were similar to the control values, delayed formation of germinal centers in lymphoid nodules and impaired migration of neutrophils to the red pulp and marginal zone were revealed in DDT-exposed rats. Along with these signs, the processes of hematopoiesis were more active in the spleen, which in general indicates a delay in its functional maturation as an organ of the immune system and increases the risk of impaired development of immune reactions.

Indexed as

DDTEndocrine DisruptorsPrenatal Exposure Delayed EffectsSexual MaturationSpleenAnimalsFemaleGerminal CenterHematopoiesisMaleNeutrophilsOrgan SizePregnancyRatsRats, WistarDDTEndocrine Disruptorsendocrine disruptorgerminal centerhemopoiesisneutrophilspleen

Identifiers

PMID41507477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.