Evidence map›Paper›PMID 41507403›Full record

ArticleCommunications biology2026

Excessive daytime sleepiness in parkinsonism is associated with cortical and basal ganglia beta oscillatory activity.

Ajay K Verma, Kit Acedillo, Bharadwaj Nandakumar, Noah Hjelle, Hannah E Baker, David D Schneck, Biswaranjan Mohanty, Mark Fiecas, Jing Wang, Michael J Howell and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ajay K VermaDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Kit AcedilloDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Bharadwaj NandakumarDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Noah HjelleDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Hannah E BakerDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
David D SchneckMasonic Institute for Developing Brain, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0009-0006-9570-8571
Biswaranjan MohantyDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-3924-039X
Mark FiecasDivision of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, MN, USA.
Jing WangDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Michael J HowellDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Colum D MacKinnonDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Jerrold L VitekDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-2308-6535
Luke A JohnsonDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA. joh03032@umn.edu.ORCID http://orcid.org/0000-0002-9069-1436

Funding

Deep Brain Stimulation in the Parkinsonian MonkeyR01NS037019 · NINDS · UNIVERSITY OF MINNESOTA · PI Jerrold L Vitek · 1999 to 2026
$14.5M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
Neurophysiological Mechanisms Underlying Parkinsonian Motor SignsR01NS058945 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON, Jerrold L Vitek · 2008 to 2026
$9.6M
The Effects of Parkinsonism and Deep Brain Stimulation on Basal Ganglia-Thalamocortical Circuitry During Sleep-Wake BehaviorR01NS110613 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON · 2019 to 2026
$4.7M
Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian MonkeyR37NS077657 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2018 to 2024
$4.4M
Optimizing coordinated reset deep brain stimulation for Parkinson's diseaseR01NS117822 · NINDS · UNIVERSITY OF MINNESOTA · PI WANG, JING · 2020 to 2024
$3.0M
Sleep-specific DBS therapy in Parkinson's diseaseR01NS131371 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON · 2023 to 2026
$2.4M
NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS037019NINDS NIH HHS R01 NS058945NINDS NIH HHS R01 NS110613NINDS NIH HHS R01 NS117822NINDS NIH HHS R01 NS131371NINDS NIH HHS R37 NS077657
6 · The paper itself

Abstract

Excessive daytime sleepiness, i.e., the inability to sustain wakefulness during the day, is a common Parkinson's disease (PD) non-motor symptom. Elevated cortico-basal ganglia beta oscillatory power (8-35 Hz) is a pathophysiological signature of PD motor signs. The relationship between beta oscillatory power and daytime sleepiness, however, remains unclear. Here, we examined the relationship between beta power and daytime vigilance in parkinsonian nonhuman primates. We administered dopaminergic medication to alter cortico-basal ganglia beta power and measured its effect on daytime vigilance. The beta power from motor cortex (MC) and subthalamic nucleus (STN), and wake quantity were derived in the following conditions: OFF-medication, ON-medication, and decay of medication effect. STN low-beta (8-20 Hz) power negatively correlated with wake quantity, suggesting that elevated STN low-beta power could disrupt sustenance of wakefulness. The cortical low-beta power did not correlate with wakefulness. Interestingly, STN and MC high-beta (21-35 Hz) power positively correlated with wake quantity. Our data provide evidence for an association between beta power and daytime vigilance in parkinsonism in addition to its known relationship with PD motor signs. These findings could inform targeted treatments to promote wakefulness in PD by selectively suppressing (e.g., low-beta) and/or amplifying (e.g., high-beta) cortico-basal ganglia beta oscillatory power.

Indexed as

Basal GangliaBeta RhythmMotor CortexParkinsonian DisordersAnimalsFemaleMacaca mulattaMaleSubthalamic NucleusWakefulness

Identifiers

PMID41507403
PMCPMC12891659

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.