Evidence map›Paper›PMID 41507402›Full record

ArticleImmunologic research2026

Association of HLA-B alleles with familial mediterranean fever (FMF): A comparative study.

Utku Aksu, Pınar Aksu Kılıçle, Sevim Gönen

Erratum issuedAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Immunologic research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Utku AksuGazi University Faculty of Medicine, Ankara, Türkiye.
Pınar Aksu KılıçleKafkas University Faculty of Science and Letter, Kars, Türkiye.
Sevim GönenGazi University Faculty of Medicine, Ankara, Türkiye. sevgonen@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFamilial Mediterranean Fever (FMF) is the most prevalent monogenic autoinflammatory disorder. In the present study, we investigated whether HLA-B polymorphisms contribute to familial Mediterranean fever (FMF) susceptibility and phenotypic variability.

methodsWe enrolled 50 familial Mediterranean fever (FMF) patients, 40 asymptomatic Mediterranean FeVer (MEFV) mutation carriers, and 50 healthy controls. HLA-B genotypes were determined by the PCR-SSO technique. Allele frequencies were compared using chi-square or Fisher's exact tests.

resultsHLA-B*51 and HLA-B*35 alleles were enriched among FMF patients compared with controls (p = 0.01 and p = 0.03, respectively). HLA-B*27 was moderately increased in patients (p = 0.04), while HLA-B*44 tended to be more common in carriers (p = 0.07). Odds ratio (OR) and confidence interval (CI) analyses indicated an elevated FMF risk for carriers of HLA-B*51 and HLA-B*35.

conclusionHLA-B variants, particularly B*51 and B*35, may act as immunogenetic modifiers of FMF, supporting the concept of MHC class I linked inflammatory pathways contributing to disease heterogeneity.

Indexed as

Familial Mediterranean FeverHLA-B35 AntigenHLA-B51 AntigenHLA-B AntigensAdolescentAdultAllelesCytoskeletal ProteinsFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedMutationCytoskeletal ProteinsHLA-B35 AntigenHLA-B51 AntigenHLA-B AntigensMEFV protein, humanPyrin

Identifiers

PMID41507402

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