Evidence map›Paper›PMID 41507398›Full record

ArticlePediatric research2026

Impact of posthemorrhagic ventricular dilatation on cerebral oxygenation in preterm infants with intraventricular hemorrhage.

Julia Elis, Lisa Klein, Mirjam Steiner, Katharina Moser, Vito Giordano, Gabriel A Vignolle, Lucia Ciglar, Gregor Kasprian, Georg Langs, Monika Olischar and 2 more

Abstract read
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In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julia ElisDepartment of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Full Member of ERN EpiCare, Medical University of Vienna - Comprehensive Center for Pediatrics, Vienna, Austria.
Lisa KleinDepartment of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Full Member of ERN EpiCare, Medical University of Vienna - Comprehensive Center for Pediatrics, Vienna, Austria.
Mirjam SteinerDepartment of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Full Member of ERN EpiCare, Medical University of Vienna - Comprehensive Center for Pediatrics, Vienna, Austria.
Katharina MoserDepartment of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Full Member of ERN EpiCare, Medical University of Vienna - Comprehensive Center for Pediatrics, Vienna, Austria.
Vito GiordanoDepartment of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Full Member of ERN EpiCare, Medical University of Vienna - Comprehensive Center for Pediatrics, Vienna, Austria.
Gabriel A VignolleCenter for Health & Bioresources, Competence Unit Molecular Diagnostics, AIT Austrian Institute of Technology GmbH, Vienna, Austria.
Lucia CiglarCenter for Health & Bioresources, Competence Unit Molecular Diagnostics, AIT Austrian Institute of Technology GmbH, Vienna, Austria.
Gregor KasprianDepartment of Biomedical Imaging and Image-guided Therapy, Division of Neuroradiology and Musculoskeletal Radiology, Medical University of Vienna, Vienna, Austria.
Georg LangsDepartment of Biomedical Imaging and Image-guided Therapy, Computational Imaging Research Lab, Medical University of Vienna, Vienna, Austria.
Monika OlischarDepartment of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Full Member of ERN EpiCare, Medical University of Vienna - Comprehensive Center for Pediatrics, Vienna, Austria.
Angelika BergerDepartment of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Full Member of ERN EpiCare, Medical University of Vienna - Comprehensive Center for Pediatrics, Vienna, Austria.
Katharina GoeralDepartment of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Full Member of ERN EpiCare, Medical University of Vienna - Comprehensive Center for Pediatrics, Vienna, Austria. katharina.goeral@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-5209-6169

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess the longitudinal effects of intraventricular hemorrhage (IVH) and posthemorrhagic ventricular dilatation (PHVD) on cerebral oxygenation using near-infrared spectroscopy (NIRS).

methodsThis prospective cohort study included preterm neonates born <34 weeks' gestation between 2013 and 2024. Regional cerebral oxygen saturation (rScO

resultsA total of 154 preterm infants with IVH (median gestational age: 25

conclusionIVH and PHVD profoundly impair cerebral oxygenation. High-grade IVH leads to rScO IMPACT: Cerebral oxygenation declines with increasing intraventricular hemorrhage (IVH) severity in preterm infants. Posthemorrhagic ventricular dilatation (PHVD) severity, reflected by the number of neurosurgical interventions, is linked to worsening cerebral oxygenation and increased oxygen extraction. This prospective cohort study provides a comprehensive longitudinal dataset using near-infrared spectroscopy (NIRS) to link IVH severity and PHVD to cerebral oxygenation dynamics. Findings underscore the urgent need for targeted neuroprotective interventions to stabilize brain oxygenation in preterm infants with severe IVH and PHVD.

Indexed as

Cerebral HemorrhageCerebral Intraventricular HemorrhageCerebral VentriclesOxygenCerebrovascular CirculationDilatation, PathologicFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMaleOxygen SaturationProspective StudiesSpectroscopy, Near-InfraredOxygen

Identifiers

PMID41507398
PMCPMC13102702

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.