Evidence map›Paper›PMID 41507389›Full record

ArticleNature immunology2026

The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types.

Jayashree Srinivasan, Colin R Moore, Aparna Calindi, Bryan R Helm, Yilin Yang, John F Moore, Hilary J Selden, Cody N Heiser, Qi Liu, Ken S Lau and 1 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jayashree Srinivasan *Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0001-9478-7518
Colin R Moore *Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0009-0009-5515-2080
Aparna Calindi *Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0009-0000-1176-2746
Bryan R HelmDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Yilin YangDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID http://orcid.org/0009-0000-9869-4044
John F MooreDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Hilary J SeldenDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Cody N HeiserProgram in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Qi LiuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Ken S LauDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-8438-0319
Lauren I R EhrlichDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. lehrlich@austin.utexas.edu.ORCID http://orcid.org/0000-0002-1697-1755

Funding

Project 3 - Differential contribution of thymic APCs to central tolerance during the perinatal to adult transitionP01AI139449 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI RICHIE, ELLEN R · 2020 to 2024
$12.0M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) P01AI139449NIAID NIH HHS P01 AI139449U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) P01AI139449
6 · The paper itself

Abstract

Dendritic cells are essential for establishing thymic central tolerance; however, mechanisms supporting their homeostasis and activation remain unresolved. Through single-cell transcriptomics and functional assays, we identify seven thymic conventional dendritic cell (cDC) subsets and discriminate their abilities to present self-antigens and induce regulatory T cells. Mice blocked at different stages of T cell development revealed that CD4

Indexed as

Cell DifferentiationDendritic CellsThymocytesThymus GlandAnimalsCD40 AntigensCentral ToleranceLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutSignal TransductionT-Lymphocytes, RegulatoryCD40 Antigens

Identifiers

PMID41507389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.