ArticleLangenbeck's archives of surgery2026
Risk and protective factors for anastomotic insufficiency in elective colon and rectal cancer resections - a multivariate analysis with over 700 patients.
Article in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to identify the risk factors and protective factors for AL.
methodsData from 717 patients with colorectal cancer with primary anastomosis who underwent elective surgery between 2012 and 2019 (418 patients with colon and 299 patients with rectal cancer) were extracted from prospectively established and retrospectively analyzed databases of two certified colorectal cancer centers, and processed for pre-, intra-, and postoperative risk factors in a multivariate analysis.
resultsAL occurred in 33 (7.6%) patients with colon cancer and 30 (10%) patients with rectal cancer. AL was more likely after (extended) left hemicolectomy/sigmoidectomy (OR 3.771; 95% CI 1.17–12.154; p = 0.026) and in combination with perioperative administration of blood transfusions (OR 2.926; 95% CI 1.013–8.455; p = 0.047) in colon surgery. BMI ≥ 30 kg/m2 significantly increased the probability of AL (OR 7.136; 95% CI 2.248–12.651; p < 0.001) in rectal cancer surgery. Preoperative oral antibiotics, mainly in combination with mechanical bowel preparation, were associated with a reduced AL rate in both entities (OR 0.199, 95% CI 0.064–0.617; p = 0.005 for colon; OR 0.278, 95% CI 0.078–0.985; p = 0.047 for rectal cancer), regardless the antibiotic regimen used. The number required for treatment was calculated as 15.94.
conclusionOur study, reflecting daily clinical practice, confirmed known risk factors (left-sided resection, perioperative blood transfusions, obesity) and identified oral antibiotics as the only protective factor against AL. The application of a single or double oral dose of two antibiotics is safe and pragmatic and should be implemented in standard operative procedures for colorectal cancer surgery.
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