Evidence map›Paper›PMID 41507369›Full record

ArticleCommunications biology2026

Eleutheroside E alleviates cisplatin-induced ototoxicity by down-regulating MAPK/NF-κB/NLRP3 signaling pathway and inhibiting cochlear cell pyroptosis.

Ya'nan Zhang, Ling Lu, Busheng Tong, Jingjing Wang, Kunjian Liu, Jialiang Zhang, Di Zhang, Meihui Tian, Weifang Sun, Huan Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ya'nan Zhang *Central Hospital of Changchun City, Changchun, China.
Ling Lu *Department of Otorhinolaryngology-Head and Neck Surgery, Zhongda Hospital, Southeast University, Nanjing, China.
Busheng TongDepartment of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Jingjing WangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Kunjian LiuWeifang Traditional Chinese Hospital, Weifang, China.
Jialiang ZhangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Di ZhangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Meihui TianChangchun University of Chinese Medicine, Changchun, China.
Weifang SunChangchun University of Chinese Medicine, Changchun, China.
Huan LiuChangchun University of Chinese Medicine, Changchun, China.
Ping WangDepartment of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin University, Changchun, China. wang_ping@jlu.edu.cn.ORCID http://orcid.org/0000-0003-1715-8421
Maoli DuanDepartment of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. maoliduan@gmail.com.ORCID http://orcid.org/0000-0002-8437-1583
Yong TangCentral Hospital of Changchun City, Changchun, China. tangyong@ccucm.edu.cn.ORCID http://orcid.org/0000-0002-6387-953X

Funding

National Natural Science Foundation of China (National Science Foundation of China) Project No. 82471185
6 · The paper itself

Abstract

Cisplatin is a broad-spectrum anticancer agent. Its main side effect - ototoxicity - may impact the quality of patient's life. Eleutheroside E (EE), the main active component of Acanthopanax, exhibits antioxidant and anti-inflammatory properties. This study investigates the protective effects of EE against cisplatin-induced ototoxicity and its underlying mechanisms. We use C57BL/6 J mice, the House Ear Institute-Organ of Corti 1 (HEI-OC1) cells, and cultured cochlear basement membranes in our experiments. We employ network pharmacology and 4D-FastDIA quantitative proteomic analysis. Our results demonstrate that Cisplatin significantly impairs auditory function in mice. However, EE co-treatment preserves auditory function across most measured frequencies, correlating with reduced damage to cochlear hair cells and spiral ganglion neurons(SGNs). Here, we show that EE attenuates cisplatin-induced pro-inflammatory responses and cellular pyroptosis, possibly via downregulation of the MAPK/NF-κB/NLRP3 signaling pathway. In conclusion, EE may offer a promising strategy for reducing Cisplatin's ototoxicity without affecting its antitumor efficacy.

Indexed as

CisplatinCochleaGlucosidesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinOtotoxicityPyroptosisAnimalsAntineoplastic AgentsDown-RegulationMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLSignal TransductionAntineoplastic AgentsCisplatinGlucosidesNF-kappa BNLR Family, Pyrin Domain-Containing 3 Protein

Identifiers

PMID41507369
PMCPMC12894672

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.