ArticleCommunications biology2026
Cortical hierarchy and aphasia severity: the sensorimotor-association gradient modulates lesion effects within language-specific networks.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Infarction volume modulates and corrects left hemisphere bias in the NIHSS for middle cerebral artery stroke.Frontiers in neuroscience · 2026Article
- The nonlinear trajectory of post-stroke aphasia recovery.Frontiers in human neuroscience · 2026Review
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Authors and funding
10 authors.
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Abstract
Aphasia severity after stroke varies widely and is not fully explained by lesion size or location. We propose that incorporating the brain's sensorimotor-association (S-A) gradient, reflecting cortical hierarchy, offers a biologically grounded framework for predicting language outcomes. In 236 individuals with chronic left-hemisphere stroke, we examine whether the hierarchical position of lesions in language-specific (LS) and domain-general (DG) areas modulates aphasia severity. We parcellate lesions using a cortical atlas and weigh them by each region's S-A rank. We apply hierarchical linear regression to test whether S-A ranking and its interaction with lesion volume improves prediction of Western Aphasia Battery-Revised Aphasia Quotient (WAB-R-AQ) scores. Across models, lesion volume in lower S-A regions is more detrimental than in higher-order areas. The LS-only model yields the highest explanatory power (adjusted R
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