Evidence map›Paper›PMID 41507298›Full record

ArticleScientific reports2026

Influence of CT parameters upon the quantification of sarcopenia and myosteatosis: a study with human bodies.

Issi R Vedder, Stef Levolger, Mostafa El Moumni, Marcel J W Greuter, Reinoud P H Bokkers, Alain R Viddeleer

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Issi R VedderDepartment of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. i.r.vedder@umcg.nl.
Stef LevolgerDepartment of Radiology, Maasstad Hospital, Rotterdam, The Netherlands.
Mostafa El MoumniDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Marcel J W GreuterDepartment of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Reinoud P H BokkersDepartment of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Alain R ViddeleerDepartment of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Computed tomography (CT) is increasingly being used in the quantitative assessment of body composition (CT-assessed sarcopenia and myosteatosis), but the effects of varying technical CT parameters on muscle area and density measurements remain unclear. This study analyzed muscle area and density in six human bodies scanned with varying CT parameters (tube current, tube voltage, slice thickness, and iterative reconstruction levels). Significance of differences relative to our institution’s standard CT abdomen protocol and among all individual parameters was assessed, with effect sizes calculated to evaluate the magnitude of observed changes. Small but significant differences were found within all groups of investigated parameters, with most statistical significant differences corresponding to large effect sizes. Compared to our institution’s clinical protocol, tube current showed significant variation in measured muscle area (p < 0.001), but no significant changes in regard to muscle density. Tube voltage and reconstruction level type both showed a significant direct relationship with muscle area (p < 0.001) and inverse relationship with muscle density (p < 0.001). Also, a slice thickness of 0.6 mm, compared to 1 mm, showed significant differences in both muscle area and density (p < 0.001), where no significant variation was observed between 1 mm and thicker slices. In conclusion, CT technical parameters significantly affect muscle area and density measurements. Although individual differences are small, their cumulative effect may lead to clinically significant discrepancies.

Indexed as

Muscle, SkeletalSarcopeniaTomography, X-Ray ComputedAgedAged, 80 and overBody CompositionFemaleHumansMaleMiddle AgedComputed tomographyMyosteatosisSarcopeniaSlice thicknessTube currentTube voltage

Identifiers

PMID41507298
PMCPMC12856011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.