Whole genome sequencing data of early- and late-onset colorectal cancer in 99 Korean patients.

Colorectal cancer (CRC) is the third most prevalent cancer type worldwide. Despite improvements in screening programs, the incidence of early-onset CRC (EOCRC) in patients under 50 years old is rapidly increasing, including in Korea, in contrast to the decreasing trend of late-onset CRC (LOCRC). However, a comprehensive biological understanding of CRC's coding and non-coding variants, onset-dependent prognostic variables, and the genetic and transcriptomic differences between EOCRC and LOCRC remains limited. To provide insights into this, we present a high-quality multi-omics dataset consisting of whole genome sequencing (WGS) and RNA sequencing (RNA-seq) data from 49 EOCRC and 50 LOCRC patients. WGS was performed using the DNBSEQ-T7 platform, generating 1.409 billion reads at an average depth of 37.70×. RNA-seq data previously generated from the same samples are included to support integrative analysis. This dataset enables comprehensive exploration of genomic and transcriptomic alterations in CRC and serves as a valuable resource for identifying onset-specific biomarkers and molecular features, ultimately supporting improved diagnosis and therapeutic strategies.