Evidence map›Paper›PMID 41507214›Full record

ArticleNPJ biofilms and microbiomes2026

Multiomics analysis reveals the exacerbating effect of constipation on autism-related symptoms in children with autism spectrum disorder.

Hailin Li, Xiuhong Li, Xin Wang, Lizi Lin, Muqing Cao, Shuolin Pan, Xiaoxuan Ou, Tingfeng Gu, Shuli Shen, Hailin Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ biofilms and microbiomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hailin LiDepartment of Child and Adolescent Health and Health Education, School of Public Health, Inner Mongolia Medical University, Hohhot, China.
Xiuhong LiSchool of Public Health, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Xin WangLaboratory of Brain, Cognition and Education Sciences, Ministry of Education; Institute for Brain Research and Rehabilitation, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China.
Lizi LinDepartment of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Muqing CaoSchool of Sport and Health, Guangzhou Sport University, Guangzhou, China.
Shuolin PanLaboratory of Brain, Cognition and Education Sciences, Ministry of Education; Institute for Brain Research and Rehabilitation, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China.
Xiaoxuan OuDepartment of Child Health, Guangzhou Women and Childrens Medical Center, Guangzhou, China.
Tingfeng GuDepartment of Emergency Management and Health Security, Guangzhou Center for Disease Control and Prevention (Guangzhou Health Supervision Institute), Guangzhou, China.
Shuli ShenDepartment of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Hailin LiDepartment of Child and Adolescent Health and Health Education, School of Public Health, Inner Mongolia Medical University, Hohhot, China. 13246463625@163.com.
Jin JingDepartment of Child and Adolescent Health and Health Education, School of Public Health, Inner Mongolia Medical University, Hohhot, China. jingjin_sysu@163.com.

Funding

2024 Inner Mongolia Autonomous Region Level Talent Introduction Research Support Program RZ2500001515Discipline Construction Project of Inner Mongolia Medical University DC2400002514 and RZ2500000582Guangdong Basic and Applied Basic Research Foundation 2022B1515130007National Natural Science Foundation of China 52400247 and 82574037Natural Science Foundation of Inner Mongolia Autonomous Region of China 2025QN08121
6 · The paper itself

Abstract

This study investigated the relationship between constipation and autism-related symptoms in children with autism spectrum disorder (ASD). Participants were assessed for gastrointestinal (GI) and autism-related symptoms and classified into constipated and non-constipated groups. The relationship was further explored via 16S rRNA sequencing and non-targeted metabolomics to identify underlying mechanisms. Results revealed that constipated ASD children exhibited more severe autism-related symptoms and alterations in four bacterial taxa-the phylum Bacteroidetes, the family Barnesiellaceae, and the genera Alistipes and Bilophila-plus 451 metabolites compared to non-constipated ASD children. Among the altered bacterial taxa, three-Bacteroidetes, Alistipes, and Bilophila-exacerbated the relationship between constipation and autism-related symptoms. Five metabolites derived from the above three taxa-chenodeoxycholic acid, palmitic acid, glutaric acid, arachidonic acid, and choline-were significantly associated with autism-related symptoms. Our multi-omics analysis reveals the exacerbating effect of constipation on autism-related symptoms in children with ASD.

Indexed as

Autism Spectrum DisorderBacteriaConstipationChildFecesFemaleGastrointestinal MicrobiomeHumansMaleMetabolomeMetabolomicsMultiomicsRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID41507214
PMCPMC12852942

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.