ArticleNature communications2026
Efficient synthesis of chiral vicinal diamines with four contiguous stereocenters via sequential dynamic kinetic resolution of 2,3-diamino-1,4-diketones.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The stereoselective construction of chiral vicinal diamines bearing multiple contiguous stereocenters remains a formidable challenge in modern organic synthesis. Herein, we report an Ir-catalyzed sequential dynamic kinetic resolution of 2,3-diamino-1,4-diketones that furnishes acyclic vicinal diamines containing four contiguous stereocenters in high yields with excellent diastereo- and enantioselectivity. The protocol exhibits broad substrate generality and high catalytic efficiency, enabling streamlined access to structurally diverse, functionally enriched chiral vicinal diamines. A gram-scale reaction proceeds smoothly with only 0.1 mol% catalyst loading, and versatile downstream derivatizations further highlights the synthetic utility of the method. Mechanistic investigations support a stepwise dynamic kinetic resolution pathway operative in this transformation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.