Evidence map›Paper›PMID 41507158›Full record

ArticleNature communications2026

Dynamins maintain nuclear envelope homeostasis and genome stability.

Célia Aveleira, Thibaud Martial, Loïc Carrique, Rita Gaspar, Ana Caulino-Rocha, Izaak Myatt, Franz Wendler, Pauline Lascaux, Misha Le Claire, James Bancroft and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Célia AveleiraMultidisciplinary Institute of Aging, Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
Thibaud MartialCentre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0009-0008-3418-5855
Loïc CarriqueDivision of Structural Biology (STRUBI), Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5332-8593
Rita GasparMultidisciplinary Institute of Aging, Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
Ana Caulino-RochaMultidisciplinary Institute of Aging, Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
Izaak MyattCentre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Franz WendlerCentre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Pauline LascauxDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-3935-6795
Misha Le ClaireDivision of Structural Biology (STRUBI), Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
James BancroftCentre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Carl SmytheSchool of Biosciences, University of Sheffield, Sheffield, UK.
Kristijan RamadanDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Nuno RaimundoMultidisciplinary Institute of Aging, Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0000-0002-5988-9129
Ira MilosevicMultidisciplinary Institute of Aging, Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. Ira.Milosevic@well.ox.ac.uk.ORCID http://orcid.org/0000-0001-6440-3763

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P41 GM103311Wellcome Trust
6 · The paper itself

Abstract

The nuclear envelope is a protective barrier for the genome and a mechanotransduction interface between cytoplasm and nucleus, whose malfunction disrupts nucleocytoplasmic transport, compromises DNA repair, accelerates telomere shortening, and promotes genomic instability. Mechanisms governing nuclear envelope remodeling and maintenance in interphase and post-mitotic cells remain poorly understood. Here, we report a role for dynamins, a family of essential brain-enriched membrane- and microtubule-binding GTPases, in preserving nuclear envelope and genomic homeostasis. Cells lacking dynamins exhibit nuclear envelope dysmorphisms, including buds with long narrow necks where damaged DNA frequently accumulates. These cells also show impaired autophagic clearance, reduced levels of key DNA repair proteins, and aberrant microtubules. Nocodazole treatment restores nuclear morphology and reduces DNA damage. Collectively, the data reveal that dynamins promote nuclear envelope homeostasis and removal of damaged DNA via their GTPase activity and interaction with microtubules, providing insights into mechanisms that uphold genome stability and counteract aging-related pathologies.

Indexed as

Genomic InstabilityHomeostasisNuclear EnvelopeAnimalsAutophagyDNA DamageDNA RepairHumansMiceMicrotubulesNocodazoleNocodazole

Identifiers

PMID41507158
PMCPMC12876909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.