Evidence map›Paper›PMID 41507156›Full record

ArticleNature communications2026

Molecular mechanism of exchange coupling in CLC chloride/proton antiporters.

Deniz Aydin, Chih-Ta Chien, Jürgen Kreiter, Amy R Nava, Jasmina M Portasikova, Lukas Fojtik, Briana L Sobecks, Catalina Mosquera, Petr Man, Ron O Dror and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Deniz Aydin *Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2758-2480
Chih-Ta Chien *Department of Bioengineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7796-0937
Jürgen Kreiter *Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5877-762X
Amy R Nava *Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.
Jasmina M PortasikovaDepartment of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.ORCID http://orcid.org/0009-0003-4921-2792
Lukas FojtikDepartment of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
Briana L SobecksDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.
Catalina MosqueraDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.
Petr ManInstitute of Microbiology of the Czech Academy of Sciences, Division BioCeV, Prumyslova 595, Vestec, Czech Republic.ORCID http://orcid.org/0000-0002-1485-2197
Ron O DrorDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA. ron.dror@stanford.edu.ORCID http://orcid.org/0000-0002-6418-2793
Wah ChiuDepartment of Bioengineering, Stanford University, Stanford, CA, USA. wahc@stanford.edu.ORCID http://orcid.org/0000-0002-8910-3078
Merritt MadukeDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA. maduke@stanford.edu.ORCID http://orcid.org/0000-0001-7787-306X

Funding

The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
Mechanisms of CLC Transporters and Channels:R01GM113195 · NIGMS · STANFORD UNIVERSITY · PI MADUKE, MERRITT C · 2016 to 2024
$4.0M
NIGMS NIH HHS R01 GM113195NIGMS NIH HHS U24 GM129541U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM113195U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review) R01GM113195
6 · The paper itself

Abstract

The ubiquitous CLC membrane transporters are unique in their ability to exchange anions for cations. Despite extensive study, there is no mechanistic model that fully explains their 2:1 Cl

Indexed as

AntiportersChloride ChannelsChloridesEscherichia coli ProteinsCryoelectron MicroscopyEscherichia coliHydrogen-Ion ConcentrationMolecular Dynamics SimulationProtein ConformationProtonsAntiportersChloride ChannelsChloridesCLC-ec1 protein, E coliEscherichia coli ProteinsProtons

Identifiers

PMID41507156
PMCPMC12873427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.