Evidence map›Paper›PMID 41507074›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Over-expression, purification, and kinetic analysis of

Yishu Zhao, Haiying Jia, Yan Wang, Shanshan Sha, Dong An, Shufeng Yang, Lei Qian, Yufang Ma, Liming Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yishu ZhaoScientific Research Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Haiying JiaScientific Research Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Yan WangScientific Research Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Shanshan ShaDepartment of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, China.
Dong AnScientific Research Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Shufeng YangDepartment of Microbiology, Dalian Medical University, Dalian, China.
Lei QianDepartment of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, China.
Yufang MaDepartment of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, China.
Liming XuScientific Research Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.ORCID 0009-0003-6600-3458

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The N-acetylglucosamine-1-phosphate transferase (WecA)is a potential target for developing anti-tuberculosis drugs, due to its critical role in the synthesis of mycobacterial cell wall. The enzymatic study of WecA and the discovery of WecA inhibitors are therefore justified. However, WecA is a membrane protein with 11 transmembrane domains, making it difficult to be obtained, and even more difficult to perform activity studies. In order to gain sufficient WecA protein for activity investigation, the

Indexed as

Enzyme InhibitorsMycobacterium tuberculosisTransferases (Other Substituted Phosphate Groups)Alkyl and Aryl TransferasesEscherichia coliKineticsAlkyl and Aryl TransferasesEnzyme InhibitorsTransferases (Other Substituted Phosphate Groups)UDP-N-acetylglucosamine 1-carboxyvinyltransferasemembrane proteinMycobacterium tuberculosisN-acetylglucosamine-1-phosphate transferasetunicamycinWecA

Identifiers

PMID41507074
PMCPMC12784632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.