Evidence map›Paper›PMID 41506970›Full record

ArticleBritish journal of anaesthesia2026

A single-centre, randomised comparison of the performance and safety of a novel mechanomyography sensor with electromyography.

Anna S Scholze, Bernhard Ulm, Nadine Kretsch, Bettina Jungwirth, Manfred Blobner, Flora T Scheffenbichler

Registry-linked trialAbstract readEquivalence Trial
In one paragraph

Article in British journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06230653 (A Single-centre, Randomised, Prospective Agreement Study to Determine the Clinical Performance and Safety of a Best Practice Medical Device With a Novel Sensor), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06230653 unknown statusnot on this map

A Single-centre, Randomised, Prospective Agreement Study to Determine the Clinical Performance and Safety of a Best Practice Medical Device With a Novel Sensor

TypeobservationalSponsorUniversity Hospital UlmRan2024 to 2024Enrolled40ConditionsNeuromuscular Blockade
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna S ScholzeDepartment of Anaesthesiology and Intensive Care Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Bernhard UlmDepartment of Anaesthesiology and Intensive Care Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany; Department of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, University of Ulm, Ulm, Germany.
Nadine KretschDepartment of Anaesthesiology and Intensive Care Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Bettina JungwirthDepartment of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, University of Ulm, Ulm, Germany.
Manfred BlobnerDepartment of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, University of Ulm, Ulm, Germany; Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Clinical Division of General Anaesthesia and Intensive Care Medicine, Medical University of Vienna, Vienna, Austria. Electronic address: manfred.blobner@uni-ulm.de.
Flora T ScheffenbichlerDepartment of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, University of Ulm, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuantitative neuromuscular monitoring is crucial to ensure patient safety when using neuromuscular blocking agents. Although historically considered as the research standard for neuromuscular monitoring, currently, no certified mechanomyography device is available for routine clinical use. This study aimed to investigate noninferiority in precision of a newly developed mechanomyography (TOF

methodsWe conducted a prospective, interventional, single-centre agreement study comparing electromyography and mechanomyography in 33 anaesthetised adult patients. Devices were randomly installed on opposite arms. Train-of-four (TOF) ratios were measured beginning before administration of rocuronium 0.45 mg kg

resultsMechanomyography had higher repeatability coefficients than electromyography at all measured TOF intervals. Mechanomyography was partially noninferior to electromyography because the 95% confidence interval of the median difference between TOF ratios of both techniques (0.039 [0.007 to 0.042]) covered the acceptable margin during baseline, but not after recovery to TOF ratio >0.9 (0.052 [0.047 to 0.076]).

conclusionsThe TOF CLINICAL

trial registrationEUDAMED (CIV-23-06-043334); ClinicalTrials.gov (NCT06230653).

Indexed as

MyographyNeuromuscular MonitoringAdultAgedElectromyographyFemaleHumansMaleMiddle AgedNeuromuscular BlockadeNeuromuscular Nondepolarizing AgentsProspective StudiesReproducibility of ResultsRocuroniumSugammadexNeuromuscular Nondepolarizing AgentsRocuroniumSugammadexelectromyographymechanomyographyneuromuscular blocking agentneuromuscular monitoringprecision

Identifiers

PMID41506970
PMCPMC12975375

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.