ArticleJournal of the American Chemical Society2026
An Alkaloid Biosynthetic Gene Bundle in Animals.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- On the Discorhabdins Leading to the Aleutianamine Ring System: A One-Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology.Angewandte Chemie (International ed. in English) · 2026Article
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4 authors.
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Abstract
Alkaloids include some of the most impactful molecules used in science and medicine. While plant alkaloids are well explored, much less is known about the diverse bioactive alkaloids from the animal kingdom. To solve this problem, we developed a computational method to discover genes that are bundled in chromosomal regions, enabling agnostic discovery of noncanonical biosynthetic gene clusters (BGCs) without prior knowledge of what enzymes might be involved. The method was applied to marine sponges that produce oroidin and related pyrrole-imidazole alkaloids, uncovering 36 BGCs in oroidin-producing sponges, only one of which (
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