Evidence map›Paper›PMID 41506784›Full record

ArticleGenome research2026

Transcriptomic landscape of transposable elements reveals

Meilong Shi, Chuanqi Teng, Shan Zhang, Xiaobo He, Lingyun Xu, Fengxian Han, Rongqi Wen, Ganjun Yu, Jingwen Liu, Yang Feng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Meilong Shi *Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China.
Chuanqi Teng *Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China.
Shan Zhang *Center for Translational Medicine, Second Military Medical University (Naval Medical University), Shanghai 200433, China.
Xiaobo He *National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai 200433, China.
Lingyun XuSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Fengxian HanSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Rongqi WenDepartment of Precision Medicine, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China.
Ganjun YuNational Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai 200433, China.
Jingwen LiuExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yang FengCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Yanfeng WuNational Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai 200433, China; wuyf@immunol.org reny@genomics.cn jingang@smmu.edu.cn ljing@smmu.edu.cn.
Yan RenExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; wuyf@immunol.org reny@genomics.cn jingang@smmu.edu.cn ljing@smmu.edu.cn.
Gang JinDepartment of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China; wuyf@immunol.org reny@genomics.cn jingang@smmu.edu.cn ljing@smmu.edu.cn.
Jing LiSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; wuyf@immunol.org reny@genomics.cn jingang@smmu.edu.cn ljing@smmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eukaryotic genomes contain numerous transposable elements (TEs), whose dysregulation threatens genome stability and may contribute to cancer. Pancreatic adenocarcinoma (PAAD) is among the deadliest cancers, marked by abundant stroma that obscures tumor-specific molecular signals, complicating bulk-tissue analyses. Here, using 71 patient-derived PAAD organoids, we show that TE activities may potentially promote tumorigenesis and provide a source of novel immunotherapeutic targets. We identify 16 new TE-derived transcripts fused with 15 known oncogenes, exhibiting potential oncogenic function and prognostic value. Notably,

Indexed as

AdenocarcinomaDNA Transposable ElementsOncogenesPancreatic NeoplasmsTranscriptomeCell Line, TumorForkhead Box Protein M1Gene Expression Regulation, NeoplasticHumansDNA Transposable ElementsForkhead Box Protein M1

Identifiers

PMID41506784
PMCPMC12863058

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.