Evidence map›Paper›PMID 41506658›Full record

ArticleInternational journal of immunopathology and pharmacology

Repeated administration of cannabidiol decreases splenic lymphocyte subset numbers in rats.

Tara H Turkki, Maciej M Jankowski, Wojciech Glac, Piotr Badtke, Viviane M Saito, Artur H Swiergiel, Bogna M Ignatowska-Jankowska

Abstract read
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In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tara H TurkkiOkinawa Institute of Science and Technology, Neuronal Rhythms in Movement Unit, Okinawa, Japan.ORCID 0000-0001-7596-6043
Maciej M JankowskiDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland.ORCID 0000-0001-9589-3929
Wojciech GlacDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland.
Piotr BadtkeDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland.
Viviane M SaitoOkinawa Institute of Science and Technology, Memory Research Unit, Okinawa, Japan.
Artur H SwiergielDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland.
Bogna M Ignatowska-JankowskaOkinawa Institute of Science and Technology, Neuronal Rhythms in Movement Unit, Okinawa, Japan.ORCID 0000-0002-8427-1128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCannabidiol (CBD) administration (5 mg/kg) in healthy rats has been shown to significantly decrease lymphocyte subset numbers in peripheral blood without involvement of natural killer cells. The aim was to evaluate whether lymphocyte numbers also decrease in the spleen.

introductionCBD, the major non-psychotropic compound of Cannabis sp., is an effective treatment for inflammatory and autoimmune diseases with various anti-tumor effects, but the mechanisms of its long-term actions in vivo remain unclear.

methodsTo examine the effects of CBD on lymphocyte subsets in the spleen and NK cellular cytotoxicity (NKCC), adult male Wistar rats (

resultsThe results indicate that repeated administration of CBD at a dose of 5 mg/kg/day decreased splenic lymphocyte numbers, involving T and non-T/NK CD45RA+ lymphocytes but not NK cells. The effects of CB

conclusionThese results reveal that in healthy rats, CBD produces similar lymphopenic effects in the spleen as it does in peripheral blood without affecting NK cell counts or cytotoxicity.

Indexed as

CannabidiolLymphocyte SubsetsSpleenAnimalsKiller Cells, NaturalLymphocyte CountMaleRatsRats, WistarCannabidiolcannabidiolcannabisflow cytometrylymphocytelymphopenianatural killer cellsratsreceptor

Identifiers

PMID41506658
PMCPMC12783575

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.