ArticleRedox biology2026
Fetal programming of the cardiac mitochondrial permeability transition pore in male offspring from hypoxic pregnancies.
Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework.International journal of molecular sciences · 2026Review
- Maternal-Fetal Crosstalk in Cardiovascular Programming: Linking the Intrauterine Environment to Lifelong Disease Risk.Journal of cardiovascular development and disease · 2026Review
- Distinct From the Adult Paradigm: Re-Evaluate the Pathophysiological and Therapeutic Framework in Children and Adolescent Hyperlipidaemia.Current obesity reports · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
A lack of oxygen during fetal development (fetal hypoxia) permanently alters the structure and function of the heart, leading to increased susceptibility to ischemia reperfusion (IR) injury in adulthood. However, the underlying cellular mechanisms are incompletely understood. In this study, we used a rat model to understand the role of calcium, reactive oxygen species and the mitochondrial permeability transition pore (MPTP) in programming IR sensitivity in offspring from hypoxic pregnancies. Pregnant Wistar rats were subjected to either ambient oxygen (∼21 %) throughout gestation, 13 % oxygen from gestational day 6-20, or 10.5 % oxygen from gestational day 15-20 (rat term ∼ 22 days). Offspring were raised to adulthood and hearts were subjected to ex vivo IR injury during Langendorff perfusion, whilst measuring ventricular pressure, intracellular calcium, oxidative stress and NAD(P)H autofluorescence. In addition, calcium retention capacity (CRC) and MPTP components were measured in isolated mitochondria, as well as basal H
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