Evidence map›Paper›PMID 41505735›Full record

Trial reportCancer reports (Hoboken, N.J.)2026

Impact of a Reproductive Health Survivorship Care Plan on Fertility, Pregnancy Concerns, and Accessing Reproductive Healthcare Among Young Nulliparous Breast Cancer Survivors.

Ksenya Shliakhtsitsava, Shaylyn S Stark, Tanushree Prasad, Sarah Boles, Diana Chingos, Jennifer Ehren, Jessica R Gorman, Sally A D Romero, Jun J Mao, Paul Nathan and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer reports (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ksenya ShliakhtsitsavaDeparment of Pediatrics, Division of Pediatric Hematolgoy and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0003-0158-5488
Shaylyn S StarkDepartment of Critical Care, Palomar Health, Escondido, California, USA.
Tanushree PrasadHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Sarah BolesDepartment of Medicine and Moores Cancer Center, University of California, San Diego, California, USA.
Diana ChingosYoung Survival Coalition, New York, New York, USA.
Jennifer EhrenDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana, USA.
Jessica R GormanCollege of Health School of Nutrition and Public Health Health Promotion and Health Behavior Program, Oregon State University, Corvallis, Oregon, USA.ORCID 0000-0002-3950-4260
Sally A D RomeroDepartment of Obstetrics, Gynecology and Reproductive Science and Moores Cancer Center, University of California, San Diego, California, USA.ORCID 0000-0001-6028-4111
Jun J MaoIntegrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0001-9229-0380
Paul NathanDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0003-0334-0871
Saro H ArmenianDepartment of Pediatrics, City of Hope Comprehensive Cancer Center, Palo Alto, California, USA.ORCID 0000-0003-2604-8603
H Irene SuDepartment of Obstetrics, Gynecology and Reproductive Science and Moores Cancer Center, University of California, San Diego, California, USA.ORCID 0000-0002-6671-5151

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
California Breast Cancer Research Program 20OB-0144California Breast Cancer Research Program P30-CA008748Dedman Family Scholar in Clinical CareNCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundYoung patients with breast cancer frequently receive chemotherapy and/or endocrine therapy that adversely affect ovarian function, leading to fertility, pregnancy, and other reproductive health concerns. Despite available evidence-based management strategies, dissemination to survivors and healthcare providers remains limited, resulting in substantial unmet informational and care needs. Web-based survivorship care plans may offer an effective approach to address these gaps.

aimsTo evaluate the effect of a web-based Reproductive Health Survivorship Care Plan (SCP-R) on reproductive concerns and reproductive healthcare access among nulliparous young breast cancer survivors (YBCS). METHODS AND

resultsThis is a secondary analysis of a 24-week randomized controlled trial on the effectiveness of a web-based SCP-R addressing unmet informational and clinical management needs for breast cancer survivors aged 18-50 years. The current analysis is restricted to nulliparous participants ages 18-40. The primary outcomes are improvement in fertility and pregnancy health concerns, as measured by the Reproductive Concerns After Cancer (RCAC) scale. The secondary outcome is fertility specialist access measured by referral, consultation, or treatment by a fertility specialist. Among 182 study participants from the parent trial, 47 met the inclusion criteria for the current study (17 in the intervention and 30 in the attention control). Mean age at diagnosis was 30.7 (SD = 3.5) years, and mean age at study participation was 34.0 (SD = 3.8) years. Fertility potential and pregnancy concerns improved in 35.3% of participants randomized to the intervention arm compared to 10.0% in the control arm (RR = 3.5, 95% CI = 1.01-12.34, p = 0.05). Intervention arm participants were significantly more likely to receive a fertility specialist referral, schedule a fertility consult, or undergo fertility treatment (37.5% in the intervention arm vs. 6.7% in the control arm; RR = 5.6, 95% CI = 1.28-24.73, p = 0.02).

conclusionsThe web-based SCP-R intervention led to improvements in fertility potential and pregnancy concerns over time and resulted in more YBCS accessing fertility specialists, highlighting the importance of age- and parity-specific survivorship care interventions to address reproductive health concerns.

Indexed as

Breast NeoplasmsCancer SurvivorsFertilityHealth Services AccessibilityPatient Care PlanningReproductive HealthAdolescentAdultFemaleFertility PreservationHumansMiddle AgedParityPregnancySecondary Data AnalysisSurvivorshipbreast cancerfertility concernspregnancy concernsrandomized controlled trialreproductive healthsurvivorship care plan

Identifiers

PMID41505735
PMCPMC12782588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.