ArticleProceedings of the National Academy of Sciences of the United States of America2026
SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
35 authors.
Yue ZhangDepartment of Bioengineering, University of California, Los Angeles, CA 90095.ORCID 0000-0001-7822-8716
Carlos Silvestre-Roig *Institute of Experimental Pathology, Center for Molecular Biology of Inflammation, University Hospital Münster, University of Münster, Münster 48143, Germany.
Han Fu *Material Science and Engineering, School of Engineering, Westlake University, Hangzhou, Zhejiang 310012, China.
Haleh Alimohamadi *Department of Bioengineering, University of California, Los Angeles, CA 90095.
Taraknath MandalDepartment of Chemistry, Boston University, Boston, MA 02215.
Jonathan W ChenDepartment of Bioengineering, University of California, Los Angeles, CA 90095.ORCID 0000-0001-5283-243X
Elizabeth Wei-Chia LuoDepartment of Bioengineering, University of California, Los Angeles, CA 90095.
Jaime de AndaDepartment of Bioengineering, University of California, Los Angeles, CA 90095.ORCID 0000-0003-2129-0775
Anna Lívia Linard MatosInstitute of Experimental Pathology, Center for Molecular Biology of Inflammation, University Hospital Münster, University of Münster, Münster 48143, Germany.ORCID 0000-0001-7174-3504
Mathis RichterInstitute of Experimental Pathology, Center for Molecular Biology of Inflammation, University Hospital Münster, University of Münster, Münster 48143, Germany.
Anna MennellaIstituto Superiore di Sanità, National Center for Global Health, Roma 00161, Italy.
HongKyu LeeDivision of Molecular Medicine, Harbor-University of California Los Angeles Medical Center Los Angeles County, Torrance, CA 90502.
Liana C ChanDivision of Molecular Medicine, Harbor-University of California Los Angeles Medical Center Los Angeles County, Torrance, CA 90502.ORCID 0000-0003-2567-4418
Yingrui WangAffiliated Hangzhou First People's Hospital, Westlake University, Hangzhou, Zhejiang 02215, China.ORCID 0000-0001-5532-3454
Naixin WangDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, China.
Hongyu WangMaterial Science and Engineering, School of Engineering, Westlake University, Hangzhou, Zhejiang 310012, China.
Xiaohan WangResearch Center for Industries of the Future, Westlake University Hangzhou, Zhejiang 310024, China.
Calvin K LeeDepartment of Bioengineering, University of California, Los Angeles, CA 90095.ORCID 0000-0001-6789-0317
Susmita GhoshLeibniz-Institut für Analytische Wissenschaften, Dortmund 44139, Germany.
Tsutomu MatsuiStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
Thomas M WeissStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
Tiannan GuoAffiliated Hangzhou First People's Hospital, Westlake University, Hangzhou, Zhejiang 02215, China.ORCID 0000-0003-3869-7651
Maomao ZhangDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, China.
Dapeng LiResearch Center for Industries of the Future, Westlake University Hangzhou, Zhejiang 310024, China.
Matthew C WolfgangDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599.ORCID 0000-0003-4534-6470
Robert S HaganMarsico Lung Institute, The University of North Carolina at Chapel Hill School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Melody M H LiDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.
Matthias GunzerLeibniz-Institut für Analytische Wissenschaften, Dortmund 44139, Germany.
Albert SickmannLeibniz-Institut für Analytische Wissenschaften, Dortmund 44139, Germany.
Loredana FrascaIstituto Superiore di Sanità, National Center for Global Health, Roma 00161, Italy.
Michael R YeamanDivision of Molecular Medicine, Harbor-University of California Los Angeles Medical Center Los Angeles County, Torrance, CA 90502.ORCID 0000-0002-9468-5252
Roberto LandeIstituto Superiore di Sanità, National Center for Global Health, Roma 00161, Italy.
Qiang CuiDepartment of Chemistry, Boston University, Boston, MA 02215.ORCID 0000-0001-6214-5211
Oliver SoehnleinInstitute of Experimental Pathology, Center for Molecular Biology of Inflammation, University Hospital Münster, University of Münster, Münster 48143, Germany.
Gerard C L WongDepartment of Bioengineering, University of California, Los Angeles, CA 90095.ORCID 0000-0003-0893-6383
Funding
A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3MProject 3: Serological Interactions with the Mucosal Innate Immune System Regulates COVID-19 Associated Tissue Damage.U54CA260543 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOLFGANG, MATTHEW C · 2020 to 2024
$9.8MVascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4MCathelicidins in Skin ImmunityR01AI052453 · NIAID · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI GALLO, RICHARD L, NIZET, VICTOR · 2002 to 2017
$5.3MAmerican Heart Association (AHA) AHA966662American Heart Association-American Stroke Association 966662Deutsche Forschungsgemeinschaft (DFG) GU 769/10-1 GU769/15-1 and 15-2 CRC TRR332Deutsche Forschungsgemeinschaft (DFG) TRR332 A1 A2 Z1National Institute of Health T32 HL069766-21National Natural Science Foundation of China 92356310National Natural Science Foundation of China NSFC 32200763National Science Fundation DMR-2325840NCI NIH HHS U54 CA260543NHLBI NIH HHS T32 HL069766NIAID NIH HHS R01 AI052453NIGMS NIH HHS P30 GM133894NIH HHS R01AI052453NIH HHS U54-CA260543NSF (NSF) NSF-CHE-2154804UCLA W.M. Keck Foundation OCRC #21-104Zhejiang Natural Science Foundation XHD24E1301
Abstract
Immune cell populations are dysregulated in COVID-19 for currently unknown reasons: Plasmacytoid dendritic cell (pDC) populations are reduced, thus hampering antiviral responses. CD8
Indexed as
COVID-19Peptide FragmentsSARS-CoV-2Spike Glycoprotein, CoronavirusAntimicrobial PeptidesCD8-Positive T-LymphocytesCell MembraneDendritic CellsHumansAntimicrobial PeptidesPeptide FragmentsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antimicrobial peptidesCOVID-19immune cell dysregulationmembrane elasticity theorymembrane permeation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.