Evidence map›Paper›PMID 41505438›Full record

ArticlePloS one2026

Genetic analysis of LRRK2 variants in Han Chinese patients with Parkinson's disease.

Xinyue Deng, Xue Yan, Zhi Song, Wen Zheng, Hongbo Xu, Yan Yang, Jiangang Wang, Lamei Yuan, Hao Deng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinyue DengHealth Management Center, the Third Xiangya Hospital, Central South University, Changsha, China.
Xue YanHealth Management Center, the Third Xiangya Hospital, Central South University, Changsha, China.
Zhi SongDepartment of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
Wen ZhengDepartment of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
Hongbo XuCenter for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha, China.
Yan YangDepartment of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
Jiangang WangHealth Management Center, the Third Xiangya Hospital, Central South University, Changsha, China.
Lamei YuanHealth Management Center, the Third Xiangya Hospital, Central South University, Changsha, China.
Hao DengHealth Management Center, the Third Xiangya Hospital, Central South University, Changsha, China.ORCID https://orcid.org/0000-0003-3240-4352

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder, with variants in the leucine rich repeat kinase 2 gene (LRRK2) being frequent genetic causes of inherited PD. This study aimed to screen for LRRK2 variants and assess their effects on PD susceptibility in the Han Chinese population. LRRK2 variants were identified through whole exome sequencing and confirmed by Sanger sequencing in 468 unrelated PD patients and 566 controls. The identified variants were analyzed via bioinformatics predictions and statistical analyses, by interpreting existing literature and database evidence. Twelve variants were detected, including p.A419V, p.P755L, p.I786F, p.C925Y, p.M968K, p.R1067Q, p.R1320S, p.I1339M, p.P1446L, p.D1756Y, p.H2206Y, and p.G2385R. Among participants, 14.74% of PD cases and 7.24% of controls carried at least one LRRK2 variant (odds ratio [OR]: 2.2144, 95% confidence interval [CI]: 1.4728-3.3294, P = 0.0001). The residues p.P755, p.R1067, p.R1320, p.P1446, and p.D1756 are comparatively conserved. The variants p.R1067Q and p.D1756Y, absent in controls, were predicted to be damaging. Compared to controls, PD patients had higher frequencies of p.A419V (OR: 4.2820, 95% CI: 1.4047-13.0530, P = 0.0054, corrected P = 0.0324) and p.G2385R (OR: 2.1149, 95% CI: 1.2682-3.5268, P = 0.0034, corrected P = 0.0324). These findings suggest that the LRRK2 variants, p.R1067Q and p.D1756Y, may act as likely pathogenic variants in PD, while p.A419V and p.G2385R might be risk factors for increased PD susceptibility in the Han Chinese population.

Indexed as

East Asian PeopleGenetic Predisposition to DiseaseLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Parkinson DiseaseAgedCase-Control StudiesChinaFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, human

Identifiers

PMID41505438
PMCPMC12782381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.