Evidence map›Paper›PMID 41505255›Full record

ArticleCell reports2026

DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling.

Randall R Rainwater, Ana C Azevedo-Pouly, Zachary J Waldrip, Belle H Hicks, Nicholas A Callais, Brian Koss, Aaron J Storey, Lyle Burdine, Marie Schluterman Burdine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Randall R RainwaterDivision of Surgical Research, Department of Surgery, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR, USA; Arkansas Children's Research Institute, 13 Children's Way, Little Rock, AR, USA.
Ana C Azevedo-PoulyDivision of Surgical Research, Department of Surgery, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR, USA; Arkansas Children's Research Institute, 13 Children's Way, Little Rock, AR, USA.
Zachary J WaldripDivision of Surgical Research, Department of Surgery, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR, USA; Arkansas Children's Research Institute, 13 Children's Way, Little Rock, AR, USA.
Belle H HicksDivision of Surgical Research, Department of Surgery, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR, USA; Arkansas Children's Research Institute, 13 Children's Way, Little Rock, AR, USA.
Nicholas A CallaisDivision of Surgical Research, Department of Surgery, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR, USA; Arkansas Children's Research Institute, 13 Children's Way, Little Rock, AR, USA.
Brian KossDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR, USA.
Aaron J StoreyArkana Laboratories, 10810 Executive Center Drive, Little Rock, AR, USA.
Lyle BurdineDivision of Surgical Research, Department of Surgery, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR, USA; Department of Transplant Surgery, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR, USA.
Marie Schluterman BurdineDivision of Surgical Research, Department of Surgery, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR, USA; Arkansas Children's Research Institute, 13 Children's Way, Little Rock, AR, USA. Electronic address: msburdine@uams.edu.

Funding

DNA-PKcs Regulation of LAT-Mediated Early TCR Signaling in CD4+ and CD8+ T CellsR21AI173759 · NIAID · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI BURDINE, MARIE SCHLUTERMAN, KOSS, BRIAN · 2023 to 2024
$424k
NIAID NIH HHS R21 AI173759
6 · The paper itself

Abstract

Formation of the immune synapse (IS) following T cell antigen recognition includes recruitment of the linker for activation of T cells (LAT). Once at the IS, LAT tyrosines are phosphorylated, allowing it to serve as a scaffold for the formation of the "signalosome," a multiprotein complex that drives T cell receptor signaling. Here, we show that upon T cell activation, DNA-dependent protein kinase catalytic subunit (DNA-PKcs) interacts with LAT and localizes to the IS. Inhibition of DNA-PKcs diminishes LAT localization at the IS. We identified two LAT serines phosphorylated by DNA-PKcs, S224 and S241, that impact LAT tyrosine phosphorylation, protein binding, and cytokine production. Using our mouse model designed to delete DNA-PKcs expression in mature CD4

Indexed as

Adaptor Proteins, Signal TransducingDNA-Activated Protein KinaseMembrane ProteinsNeoplasmsNuclear ProteinsSignal TransductionT-Lymphocytes, CytotoxicAllograftsAnimalsCD8-Positive T-LymphocytesDNA-Binding ProteinsHumansImmunological SynapsesLymphocyte ActivationMiceMice, Inbred C57BLAdaptor Proteins, Signal TransducingDNA-Activated Protein KinaseDNA-Binding ProteinsLat protein, mouseMembrane ProteinsNuclear ProteinsPrkdc protein, mouseReceptors, Antigen, T-CellCD4(+) T cellsCD8(+) T cellsCP: immunologyDNA-PKcsDNA protein kinase catalytic subunitimmune synapseLATlinker for activated T cellssignalosomeT cell receptorT cell signalingTCR

Identifiers

PMID41505255
PMCPMC12969053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.