ArticleNucleic acids research2026
A mechanism for telomere-specific telomere length regulation.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Telomere biology and telomerase regulation across species: evolutionary insights into aging, longevity, and genome stability.Molecular biology reports · 2026Review
- Rap1-mediated steric hindrance protects telomeres from MRX sensing.Nature structural & molecular biology · 2026Article
- Determinants of chromosome-specific telomere lengths among 2573 All of Us participants.Nature communications · 2026Article
- Natural diversity of telomere length distributions across 100Genome research · 2026Article
- TARPON-A Telomere Analysis and Research Pipeline Optimized for Nanopore.PLoS computational biology · 2026Article
- The leaves fall, yet the tree endures.Cellular and molecular life sciences : CMLS · 2025Review
- Chromosome engineering points to the cis-acting mechanism of chromosome arm-specific telomere length setting and robustness of plant phenotype, chromatin structure and gene expression.The Plant journal : for cell and molecular biology · 2025Article
- The Notable Role of Telomere Length Maintenance in Complex Diseases.Biomedicines · 2024Review
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Abstract
Telomere length is a critical determinant of telomere function and hence chromosome stability. Critically short telomeres induce cellular senescence and division arrest, which eventually may lead to devastating age-related degenerative diseases. Conversely, maintenance of telomere length is a hallmark of cancer. How telomere set-length is established and molecular mechanisms for telomere-specific length regulation remained unknown. Here, we detail a mechanism of a telomere-specific set-length regulation that causes important differences in telomere length between individual telomeres in the same cell. Indeed, the results show that telomerase recruitment is modulated in cis in a telomere-specific way. Increased Sir4 abundance on yeast TEL03L subtelomeric heterochromatin leads to a set-length maintenance that is 1.5 to 2 times higher than on other telomeres. Remarkably, the distal 15 kb of TEL03L are sufficient to transfer this telomere-specific set-length regulation to another chromosome end. Furthermore, a mutation in the telomere boundary element protein Tbf1 allow increased Sir4 binding on telomeres and hence results in longer set-lengths. The results, therefore, will force a rethinking of telomere length regulation away from the generalized view that all telomeres are treated the same, to a more telomere-specific treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.