Evidence map›Paper›PMID 41505091›Full record

ArticleNucleic acids research2026

YAP-TEAD regulates the super-enhancer network to control early surface ectoderm commitment.

Zhiming Wang, Chen Yang, Ziyue Ma, Xiaoyu He, Linying Li, Yihao Wang, Yexin Wang, Xiaodong Cai, Huiyuan Jiao, Mengqi Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhiming WangDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0009-0001-0131-8139
Chen YangDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0009-0000-5728-3951
Ziyue MaDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xiaoyu HeDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Linying LiDepartment of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China.
Yihao WangDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200025, China.
Yexin WangDepartment of Oral Surgery, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Xiaodong CaiDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Huiyuan JiaoDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Mengqi ZhangDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ran TongDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Feng ZhangDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0003-3447-897X
Lingjie LiDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0003-4348-516X

Funding

National Key R&D Program of China 2021YFA1100400National Natural Science Foundation of China 32470784Natural Science Foundation of Shanghai 21ZR1435900Program for Oriental Scholars of Shanghai Universities (to L.L.)Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases (to L.L.)Shanghai Sailing Program 21YF1422600
6 · The paper itself

Abstract

Super enhancers (SEs), characterized by clusters of enhancers, are instrumental in shaping cellular identity and function. Given this crucial involvement of SEs in cell lineage commitment, and considering the pivotal position of surface ectoderm in differentiating into a wide array of cell types, the study of these SEs holds immense promise for advancing cell-based therapeutic applications. In this study, we profiled the SE landscape in surface ectoderm cells derived from pluripotent stem cell differentiation. By leveraging 3D genomic data, we discerned active histone modifications and frequent chromatin interactions of SEs with target genes. Notably, perturbing specific SE using a CRISPR-dCas9-mediated approach resulted in decreased expression of the connected gene. Subsequently, we constructed a regulatory network of core transcription factors (TFs) operating on SEs and uncovered their control over the differentiation process by forming regulatory network with key TFs, such as TEAD1. Knocking down TEADs attenuated the differentiation process and target gene activation, whereas YAP-TEAD activation expedited the differentiation process by promoting the early establishment of SEs. Collectively, our findings shed light on the crucial role of SEs and identify YAP-TEAD as vital regulators controlling surface ectoderm commitment, thereby providing a novel insight into lineage commitment and stem cell-based epithelial regeneration.

Indexed as

Adaptor Proteins, Signal TransducingDNA-Binding ProteinsEctodermNuclear ProteinsSuper EnhancersTranscription FactorsAnimalsCell DifferentiationCell LineageGene Expression Regulation, DevelopmentalGene Regulatory NetworksMicePluripotent Stem CellsTEA Domain Transcription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingDNA-Binding ProteinsNuclear ProteinsTEA Domain Transcription FactorsTranscription FactorsYap1 protein, mouseYAP-Signaling Proteins

Identifiers

PMID41505091
PMCPMC12781878

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.