ArticleBulletin of experimental biology and medicine2025
Response of Pancreatic Stellate Cells to the Development of Experimental Type 2 Diabetes Mellitus.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic stellate cells (PSCs) are involved in the homeostasis maintenance in the pancreas, but upon activation, they are capable of excessive production of extracellular matrix proteins, which can aggravate the course of the pathological process, in particular diabetes. The changes in the functional activity of PSCs in the acinar and islet parts of the pancreas in rats with experimental type 2 diabetes mellitus were assessed by the expression of GFAP and α-SMA markers, as well as by the intensity of collagen proportion. During the development of experimental type 2 diabetes mellitus, PSCs are activated in the pancreas as evidenced by enhanced expression of α-SMA accompanied by increased collagen production. We revealed a direct correlation of the levels of glucose and HbA1c with relative collagen content in the islets and the number of α-SMA+ cells. The results obtained can further contribute to the development of therapeutic strategies for the treatment of type 2 diabetes mellitus.
Indexed as
Identifiers
41505044What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.