Evidence map›Paper›PMID 41505008›Full record

ArticleVeterinary research communications2026

Activation of IL-1 and IL-18 induced by Mycobacterium neoaurum and bacillus calmette-guérin are dependent on the NLRP3 and AIM2 inflammasome.

Jihong Ren, Wen Sun, Shuyue Wang, Ying Sun, Yuze Liu, Chunfang Wang, Xiuyun Jiang

Abstract read
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In one paragraph

Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jihong Ren *College of Animal Medicine, Jilin Agricultural University, Xincheng Street No.2888, Changchun, 130118, China.
Wen Sun *College of Animal Medicine, Jilin Agricultural University, Xincheng Street No.2888, Changchun, 130118, China.
Shuyue WangCollege of Animal Medicine, Jilin Agricultural University, Xincheng Street No.2888, Changchun, 130118, China.
Ying SunCollege of Animal Medicine, Jilin Agricultural University, Xincheng Street No.2888, Changchun, 130118, China.
Yuze LiuCollege of Animal Medicine, Jilin Agricultural University, Xincheng Street No.2888, Changchun, 130118, China.
Chunfang WangCollege of Animal Medicine, Jilin Agricultural University, Xincheng Street No.2888, Changchun, 130118, China. wangchunfang@jlau.edu.cn.
Xiuyun JiangCollege of Animal Medicine, Jilin Agricultural University, Xincheng Street No.2888, Changchun, 130118, China. jiangxiuyun@jlau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nontuberculous mycobacteria (NTM) refers to all mycobacteria except Mycobacterium tuberculosis (Mtb) and Mycobacterium leprae (M. leprae). In recent years, its incidence and prevalence have been increasing worldwide, which has attracted the attention of medical and scientific research circles. We determined the immune mechanism of Mycobacterium neoaurum (M. neoaurum) and Bacillus Calmette-Guérin (BCG) by studying the association between M. neoaurum and BCG infection and the release of IL-1β and IL-18, the assembly of inflammatory body, and pyroptosis. Macrophages were infected with M. neoaurum and BCG. The secretion of IL-1β and IL-18 was detected by ELISA, and the gene expression and protein expression of IL-1β, IL-18, NLRP3, AIM2, ASC, caspase-1 and GSDMD were detected by RT-PCR and Western Blot. NLRP3 and AIM2 inflammasome assembly was induced by M. neoaurum and BCG infection in mouse macrophages, which activated caspase-1 and induced the maturation and secretion of IL-1β and IL-18. The secretion of IL-1β and IL-18 were regulated by ATP-dependent K

Indexed as

DNA-Binding ProteinsInflammasomesInterleukin-1Interleukin-18Interleukin-1betaMycobacteriumMycobacterium bovisNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsMacrophagesMiceAim2 protein, mouseDNA-Binding ProteinsInflammasomesInterleukin-1Interleukin-18Interleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseAIM2 inflammasomeBacillus Calmette-GuérinIL-18IL-1βMycobacterium neoaurumNLRP3 inflammasome

Identifiers

PMID41505008

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.