Evidence map›Paper›PMID 41504903›Full record

ArticleMedical molecular morphology2026

Relationship between nutritional indicators and clinicopathological factors, including immune cell densities in the tumor microenvironment, in patients with colorectal cancer.

Natsuko Sakaida, Rin Yamada, Kota Arima, Kohei Yamashita, Norihisa Hanada, Daiki Yoshii, Yukio Fujiwara, Chihiro Nakashita, Seiya Shimoda, Masaaki Iwatsuki and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Medical molecular morphology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Natsuko Sakaida *Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 8608556, Japan.
Rin Yamada *Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 8608556, Japan. yamada.rin@kuh.kumamoto-u.ac.jp.ORCID http://orcid.org/0000-0001-9161-1429
Kota ArimaDepartment of Surgery, Izumi General Medical Center, Kagoshima, Japan.
Kohei YamashitaDepartment of Surgery, Izumi General Medical Center, Kagoshima, Japan.
Norihisa HanadaDepartment of Surgery, Izumi General Medical Center, Kagoshima, Japan.
Daiki YoshiiDepartment of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 8608556, Japan.
Yukio FujiwaraDepartment of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 8608556, Japan.
Chihiro NakashitaDivision of Food and Health Environmental Sciences, Faculty Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto, Japan.
Seiya ShimodaDivision of Food and Health Environmental Sciences, Faculty Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto, Japan.
Masaaki IwatsukiDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Yoshihiro KomoharaDepartment of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 8608556, Japan.

Funding

Japan Society for the Promotion of Science #20H03459
6 · The paper itself

Abstract

We retrospectively analyzed 116 cases of colorectal cancer (CRC) to evaluate the relationship between nutritional indicators (NIs) and clinicopathological features, including immune cell infiltration in the tumor microenvironment. The geriatric nutritional risk index (GNRI), prognostic nutritional index (PNI), modified Glasgow prognostic score (mGPS), Controlling Nutritional Status (CONUT) score, and neutrophil-to-lymphocyte ratio (NLR) were assessed. Immune cell densities (CD3, CD8, Foxp3, Iba1, CD163) were quantified by immunohistochemistry. Poor NIs were associated with older age, lower body mass index, advanced tumor stage, elevated tumor markers, and reduced immune cell infiltration. Specifically, low GNRI and high mGPS correlated with reduced Foxp3-positive cells; low PNI with reduced Foxp3- and CD20-positive cells; and high NLR with reduced CD3-, CD8-, CD20-, and Iba1-positive cells. The GNRI- and mGPS-abnormal groups showed significantly reduced Foxp3-positive cells, and the CONUT-abnormal group exhibited decreased CD3- and CD20-positive cells. Patients with abnormal NLR had significantly worse cancer-specific survival. However, it was not identified as an independent prognostic factor in the multivariate analysis. Nutritional impairment in CRC patients is linked not only to poor clinical outcomes, but also to a tumor-promoting microenvironment characterized by diminished immune cell infiltration. Assessing NIs may help guide nutritional and therapeutic strategies to improve prognosis.

Indexed as

Colorectal NeoplasmsNutritional StatusTumor MicroenvironmentAgedAged, 80 and overBiomarkers, TumorFemaleForkhead Transcription FactorsHumansLymphocytesMaleMiddle AgedNeutrophilsNutrition AssessmentPrognosisRetrospective StudiesBiomarkers, TumorForkhead Transcription FactorsColorectal cancerControlling nutritional statusGeriatric nutritional risk indexModified glasgow prognostic scoreNeutrophil/lymphocyte ratioNutritional indicatorsPrognostic nutritional indexTumor immune microenvironment

Identifiers

PMID41504903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.