Complete Genome Sequencing of Streptomyces sp. Qhu-M197 Isolated from Alpine Meadows in the Qinghai-Tibetan Plateau Uncovers Biosynthetic Gene Clusters Encoding Bioactive Natural Products.

Xin Xiang, Jiakai Fan, Xingyu Liu, Guangzhi Li, Chenghang Sun, Benyin Zhang

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Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Xin XiangState Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, Qinghai, China.

Jiakai FanCollege of Eco-Environmental Engineering, Qinghai University, Xining, 810016, Qinghai, China.

Xingyu LiuCollege of Eco-Environmental Engineering, Qinghai University, Xining, 810016, Qinghai, China.

Guangzhi LiCollege of Eco-Environmental Engineering, Qinghai University, Xining, 810016, Qinghai, China.

Chenghang SunState Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, Qinghai, China. sunchenghang@imb.pumc.edu.cn.

Benyin ZhangState Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, Qinghai, China. benyinzhang@qhu.edu.cn.

Funding

Guiding Funds of Central Government for Supporting the Development of the Local Science and Technology, Qinghai Province 2024ZY007National Natural Science Foundation of China 31960642Open Project of State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University 2023-KF-06

6 · The paper itself

Abstract

Streptomyces spp. is a crucial source for the drug discovery and development, especially those from extreme environments. The complete genome was sequenced to uncover the biosynthetic potential of the strain Qhu-M197 producing mithramycin isolated from the alpine meadow of the Qinghai-Tibetan Plateau. The results revealed that the genome consists of one linear chromosome and two plasmids with the size of 9.12 megabases (Mb) and the guanine-cytosine (G + C) content of 71.52%. The phylogenetic analyses of 16S rRNA gene and genome of strain Qhu-M197 suggested the strain belonged to Streptomyces genus, and the closest phylogenetic relationship between the strain Qhu-M197 and S. phaeoluteigriseus DSM 41896

Indexed as

Biological ProductsGenome, BacterialMultigene FamilyStreptomycesWhole Genome SequencingBase CompositionPhylogenyRNA, Ribosomal, 16STibetBiological ProductsRNA, Ribosomal, 16SBiosynthetic gene clustersGenome sequencingNatural productsPhylogenetic analysisStreptomyces

Identifiers

PMID41504849

DOI10.3390/antibiotics8030133

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