ReviewWorld journal of microbiology & biotechnology2026
A review on novel strategies to combat multidrug resistance in pathogenic bacteria exploiting synergism between essential oil and antibiotics.
Review in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Synergistic Activity of Natural Antimicrobials Against Common Fish Spoilage and Pathogenic Bacteria.Food science & nutrition · 2026Article
- Monitoring Hygiene Protocols and Exploring Alternatives to Counteract Resistant Pathogens: A Case Study from Southern Italy on Healthcare-Associated Infection Control.Microorganisms · 2026Article
- Research progress and antibacterial mechanisms of plant essential oils as alternative therapies for periodontitis.Frontiers in microbiology · 2026Review
- A 4-methyl-substituted durlobactam analogue as a potential class-D oxacillinase inhibitor inFrontiers in bioinformatics · 2026Article
- Antibiotic resistance inFrontiers in microbiology · 2026Review
- Essential oils as nature-engineered antifungals: a comprehensive review of pharmacological mechanisms, drug synergism, and advanced formulation strategies.Frontiers in pharmacology · 2026Review
- Biofilm-associated antibiotic tolerance in the era of multidrug resistance: quorum-sensing mechanisms and emerging therapeutic strategies.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The rapid rise of multidrug-resistant (MDR) bacteria has rendered many conventional antibiotics ineffective, therefore urging the need for novel treatment approaches. In the last few years, essential oils have been studied for their potential to enhance the effectiveness of conventional antibiotics. Essential oils contain several bioactive compounds, such as terpenes and phenols. In this review we discuss how the combination of essential oils with antibiotics can be used to improve their action against antibiotic resistant bacteria, including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Combination of essential oils with antibiotics can make bacterial membranes more permeable; inhibit efflux pumps that are involved in the extrusion of drugs; interfere with bacterial biofilm formation; and decrease bacterial virulence and communication (quorum sensing). Laboratory studies, including checkerboard and time–kill assays, demonstrate that some essential oils, such as lavender, thyme, oregano, and cinnamon, can significantly reduce the antibiotic doses required to inhibit bacterial growth. Such combinations restore the effectiveness of antibiotics but, most importantly minimize side effects and increase the scope of treating bacterial infections. However, the standardization and formulations of essential oils needs further study on safety and application in a clinical setting. Upcoming technologies, including nanocarrier-based delivery systems, may enable the development of essential oil-antibiotic synergy into a practical, feasible approach in the fight against antimicrobial resistance.
Indexed as
Identifiers
41504837What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.