SynthesisEuropean journal of clinical pharmacology2026
Efficacy of Racecadotril in acute diarrhea in children: systematic review of double blind randomized clinical trials.
Synthesis in European journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute diarrhea in children is a common condition. Standard treatment is oral rehydration, but antidiarrheal drugs are still widely used. However, their efficacy is debated: several trials and meta-analyses have yielded contradictory results with a low level of evidence. Consequently, an updated and rigorous analysis is warranted.
objectiveThe aim of this study was to evaluate the efficacy of Racecadotril in acute diarrhea in children, through a systematic literature review and meta-analysis of randomized trials. We also introduce a new method for interpreting the available evidence : the REB method.
methodA bibliographic search was conducted for articles published until October 2, 2023. The risk of bias was assessed using the RoB2 tool. The three endpoints were duration of diarrhea, stool production and length of hospitalization. The REB method was used to assess the overall level of evidence for efficacy. The REB method evaluates only low-risk-of-bias RCTs with confirmatory results to assess the solidity of evidence.
resultsFive trials were selected and included 904 patients. Only one trial was assessed as having a low risk of bias, precluding meta-analysis. This study was included in the REB analysis and showed neither statistically significant nor clinically significant effects. According to the REB method, the conclusion is an “absence of evidence” for efficacy of Racecadotril on all three endpoints.
conclusionThis review found insufficient high-quality evidence to support the efficacy of Racecadotril in children with acute diarrhea.
Indexed as
Identifiers
41504802What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.