Evidence map›Paper›PMID 41504495›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

ROS Activated NETosis of Bone Marrow CD55

Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yutong GuoDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory For Dental Materials, Beijing, P. R. China.
Shengjie CuiDepartment of General Dentistry, Peking University School and Hospital of Stomatology, Beijing, P. R. China.
Xi WenDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory For Dental Materials, Beijing, P. R. China.
Yidi WangDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory For Dental Materials, Beijing, P. R. China.
Ben WuCenter For Applied Statistics, School of Statistics, Renmin University of China, Beijing, P. R. China.
Yixiang WangCentral Laboratory, Peking University School and Hospital of Stomatology, Beijing, P. R. China.
Yan GuDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory For Dental Materials, Beijing, P. R. China.ORCID 0000-0003-0108-4325

Funding

National Natural Science Foundation of China 81970920National Natural Science Foundation of China 81970979National Natural Science Foundation of China 82101043Natural Science Foundation of Beijing Municipality 7232217Natural Science Foundation of Beijing Municipality 7232218Natural Science Foundation of Beijing Municipality 7242282
6 · The paper itself

Abstract

Neutrophil NETosis is markedly dysregulated in the aging body. Bone marrow serves as the powerhouse of neutrophil differentiation, while the state of neutrophil NETosis therein and its relationship with bone aging remains largely elusive. Moreover, it remains unclear how neutrophil heterogeneity and pro-inflammatory cues within bone marrow synergistically regulate neutrophil NETosis. Here, we find neutrophil NETosis is highly activated in the bone marrow of 3-mon male senescence-accelerated mouse prone 6 (SAMP6), and the released NETs induce BMSCs senescence and impairs their osteogenesis. Further, we verify in vivo NETs-clearance significantly ameliorates bone aging of 3-mon male SAMP6 mice. Next, through scRNA-seq we find a CD55

Indexed as

AgingBone MarrowExtracellular TrapsHypoxia-Inducible Factor 1, alpha SubunitNeutrophilsReactive Oxygen SpeciesAnimalsCellular SenescenceMaleMiceOsteogenesisSignal TransductionHypoxia-Inducible Factor 1, alpha SubunitReactive Oxygen SpeciesBMSCs senescencebone agingCD55+ neutrophilsintermediate mature neutrophilsNETosisROS

Identifiers

PMID41504495
PMCPMC13042873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.