Evidence map›Paper›PMID 41504386›Full record

ReviewBiotechnology and bioengineering2026

A Guide to Bayesian Optimization in Bioprocess Engineering.

Maximilian Siska, Emma Pajak, Katrin Rosenthal, Antonio Del Rio Chanona, Eric von Lieres, Laura M Helleckes

Abstract readReview
In one paragraph

Review in Biotechnology and bioengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maximilian SiskaIBG-1: Biotechnology, Forschungszentrum Jülich, Jülich, Germany.ORCID 0000-0002-1731-559X
Emma PajakThe Sargent Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London, UK.ORCID 0009-0003-4868-6144
Katrin RosenthalSchool of Science, Constructor University, Bremen, Germany.ORCID 0000-0002-6176-6224
Antonio Del Rio ChanonaThe Sargent Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London, UK.ORCID 0000-0003-0274-2852
Eric von LieresIBG-1: Biotechnology, Forschungszentrum Jülich, Jülich, Germany.ORCID 0000-0002-0309-8408
Laura M HelleckesThe Sargent Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London, UK.ORCID 0000-0001-7825-7998

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bayesian optimization has become widely popular across various experimental sciences due to its favorable attributes: it can handle noisy data, perform well with relatively small data sets, and provide adaptive suggestions for sequential experimentation. While still in its infancy, Bayesian optimization has recently gained traction in bioprocess engineering. However, experimentation with biological systems is highly complex and the resulting experimental uncertainty requires specific extensions to classical Bayesian optimization. Moreover, current literature often targets readers with a strong statistical background, limiting its accessibility for practitioners. In light of these developments, this review has two aims: first, to provide an intuitive and practical introduction to Bayesian optimization; and second, to outline promising application areas and open algorithmic challenges, thereby highlighting opportunities for future research in machine learning.

Indexed as

BiotechnologyAlgorithmsBayes TheoremSoft ComputingBayesian optimizationbioprocess engineeringDesign of Experimentsguidelines

Identifiers

PMID41504386
PMCPMC13003447

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.