ArticleJACC. Case reports2026
Intraoperative Anaphylaxis in the Setting of Undiagnosed Alpha-Gal Syndrome: A Heart Team Clinical Conundrum.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Perioperative Considerations for Alpha-Gal Syndrome: A Literature Review and Single-Center Experience in a Highly Endemic Area.Diseases (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlpha-gal syndrome (AGS) is a delayed allergic reaction to galactose-α-1,3-galactose, a carbohydrate in nonprimate mammalian tissue. Reactions can occur in individuals exposed to lone star ticks after consuming red meat and dairy products and/or exposure to mammal-derived medications or bioprosthetic materials. CASE SUMMARY: A 74-year-old man undergoing valve and ascending aortic replacement experienced hemodynamic collapse after transfusion of heparin, fresh frozen plasma, and platelets. Transfusion reaction, cardiogenic shock, and sepsis were ruled out. Recovery occurred within 6 hours of medical treatment. After an otherwise uncomplicated hospitalization, he was diagnosed with AGS and treated with diet restriction and omalizumab. DISCUSSION AND TAKE-HOME MESSAGES: In addition to anaphylaxis, AGS may also have long-term cardiovascular effects such as early bioprosthetic valve failure, accelerated atherosclerosis, and coronary artery disease. Understanding of clinical subtleties of AGS and its cardiovascular implications is important for clinicians who manage these patients both in the short and long terms.
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