Evidence map›Paper›PMID 41504325›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Visible Light-Activated ZnO@CuO Coaxial Nanofibers Enhance Infected Skin Wound Healing Through Construction of p-n Heterojunctions.

Pengrui Dang, Han Zhao, Chenguang Zhang, Jiechen Wang, Fangyu Zhu, Qinqiu Zhong, Wenyi Zeng, Xinyuan Wang, Yumin Chen, Xu Yan and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pengrui DangDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory For Dental Materials, Beijing, China.
Han ZhaoDepartment of General Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory For Dental Materials, Beijing, China.
Chenguang ZhangHospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Jiechen WangDepartment of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fangyu ZhuDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory For Dental Materials, Beijing, China.
Qinqiu ZhongThe VIP Department, Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Wenyi ZengHospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Xinyuan WangDepartment of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yumin ChenDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory For Dental Materials, Beijing, China.
Xu YanThe VIP Department, Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0002-1873-6126
Xuliang DengDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory For Dental Materials, Beijing, China.ORCID https://orcid.org/0000-0003-1838-6274
Wenwen LiuDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory For Dental Materials, Beijing, China.ORCID https://orcid.org/0000-0002-0092-4276

Funding

China Postdoctoral Science Foundation 2023M740141Liaoning Central Guiding Local Science and Technology Development Special Fund 2024JH6/100800012National Natural Science Foundation of China 82221003National Natural Science Foundation of China 82471029National Natural Science Foundation of China U22A20314The Young Elite Scientist Sponsorship Program by CAST 2023QNRC001
6 · The paper itself

Abstract

The noninvasive regulation of photocatalytic materials for reactive oxygen species (ROS)-based antimicrobial strategies offers a promising approach for healing infected wounds under comorbid conditions. However, most ROS-generating photocatalytic materials rely on ultraviolet (UV) or near-infrared (NIR) light activation, presenting challenges for convenient application and biosafety. In this study, novel zinc oxide@copper oxide (ZnO@CuO) nanofibers with a robust coaxial structure are developed that could be activated by visible light to generate ROS through photocatalytic reactions. The orderly arrangement of the inner and outer semiconductor layers enhanced the contact efficiency of p-n heterojunctions, thereby improving the electron-hole separation efficiency in the nanofibers. The enhanced contact efficiency of p-n heterojunctions is the key mechanism driving the improved photocatalytic properties and increased ROS generation under visible light, offering greater ease of application and biocompatibility. The ZnO@CuO coaxial nanofibers exhibited excellent antimicrobial properties and accelerated wound healing under visible light in a methicillin-resistant Staphylococcus aureus (MRSA)-infected mouse skin wound model. The coaxial nanofibers controlled infection at an early stage and significantly accelerated wound healing. Even in infected diabetic wounds, a healing rate of 92.3% is achieved within 10 days. This innovative approach utilizes biosafe visible light, providing a promising solution for infected wound therapies.

Indexed as

CopperLightNanofibersSkinWound HealingZinc OxideAnimalsDisease Models, AnimalMaleMethicillin-Resistant Staphylococcus aureusMiceMice, Inbred BALB COxidants, PhotochemicalPhotochemical ProcessesReactive Oxygen SpeciesStaphylococcal Skin InfectionsCoppercupric oxideOxidants, PhotochemicalReactive Oxygen SpeciesZinc Oxideantibacterial dressingcoaxial nanofibersinfected wound healingp‐n heterojunctionvisible light photocatalysis

Identifiers

PMID41504325
PMCPMC13042498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.